Pablo Conesa

TL;DR: The MetaboLights repository, powered by the open source ISA framework, is cross-species and cross-technique and will cover metabolite structures and their reference spectra as well as their biological roles, locations, concentrations and raw data from metabolic experiments.

TL;DR: A fully automatic, accurate method for determining the local resolution of a 3D map (MonoRes), which is computationally more rapid than existing methods in the field and offers the option of local filtering of the original map based on the calculated local resolution.

TL;DR: This unit provides a guide to using MetaboLights, downloading experimental data, and depositing metabolomics datasets using user‐friendly submission tools.

TL;DR: The Framework Programme 7 EU Initiative Coordination of Standards in metabolomics (COSMOS) is developing a robust data infrastructure and exchange standards for metabolomics data and metadata as discussed by the authors, which can support workflows for a broad range of metabolomics applications within the European metabolomics community and the wider metabolomics and biomedical communities' participation.

TL;DR: This work proposes a new method for local sharpening of cryo-EM density maps, based on a local resolution-guided Wiener restoration approach of the original map, and represents the first application of local resolution in crye-EM sharpening.