P
Paraskevi Giannakakou
Researcher at Cornell University
Publications - 162
Citations - 13101
Paraskevi Giannakakou is an academic researcher from Cornell University. The author has contributed to research in topics: Prostate cancer & Taxane. The author has an hindex of 55, co-authored 155 publications receiving 11892 citations. Previous affiliations of Paraskevi Giannakakou include Spanish National Research Council & Emory University.
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Journal ArticleDOI
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.
Haiying Zhang,Daniela Freitas,Han Sang Kim,Han Sang Kim,Kristina I. Fabijanic,Zhong Li,Haiyan Chen,Haiyan Chen,Milica Tesic Mark,Henrik Molina,Alberto Benito Martin,Linda Bojmar,Justin Fang,Sham Rampersaud,Ayuko Hoshino,Irina Matei,Candia M. Kenific,Miho Nakajima,Anders P. Mutvei,Pasquale Sansone,Weston Buehring,Huajuan Wang,Juan Pablo Jimenez,Leona Cohen-Gould,Navid Paknejad,Matthew Brendel,Katia Manova-Todorova,Ana Magalhães,José Alexandre Ferreira,Hugo Osório,André M. N. Silva,Ashish Massey,Juan R. Cubillos-Ruiz,Giuseppe Galletti,Paraskevi Giannakakou,Ana Maria Cuervo,John Blenis,Robert E. Schwartz,Mary Sue Brady,Héctor Peinado,Jacqueline Bromberg,Jacqueline Bromberg,Hiroshi Matsui,Celso A. Reis,David Lyden,David Lyden +45 more
TL;DR: It is shown that AF4 can serve as an improved analytical tool for isolating extracellular vesicles and addressing the complexities of heterogeneous nanoparticle subpopulations, and three nanoparticle subsets demonstrated diverse organ biodistribution patterns, suggesting distinct biological functions.
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Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization
Paraskevi Giannakakou,Dan L. Sackett,Yoon-Koo Kang,Zhirong Zhan,Jeroen Buters,Tito Fojo,Marianne S. Poruchynsky +6 more
TL;DR: Results identify residues β270 and β364 as important modulators of paclitaxel’s interaction with tubulin as well as acquired mutations in the M40 isotype at nucleotide 810 (T → G; Phe270 → Val) in 1A9PTX10 cells and nucleotide 1092 (G → A; Ala364 → Thr) in1A 9PTX22 cells.
Journal ArticleDOI
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
Nicola J. Mabjeesh,Daniel Escuin,Theresa LaVallee,Victor S. Pribluda,Glenn M. Swartz,Michelle S. Johnson,Margaret T. Willard,Hua Zhong,Jonathan W. Simons,Paraskevi Giannakakou +9 more
TL;DR: These data establish 2ME2 as a small molecule inhibitor of HIF-1 and provide a mechanistic link between the disruption of the MT cytoskeleton and inhibition of angiogenesis.
Journal ArticleDOI
Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)
TL;DR: The epothilones are competitive inhibitors of the binding of [3H]paclitaxel to tubulin polymers, and there were different proportions of various mitotic aberrations following treatment with different drugs.
Journal ArticleDOI
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
Paraskevi Giannakakou,Rick Gussio,Eva Nogales,Kenneth H. Downing,Daniel W. Zaharevitz,Birgit Bollbuck,George Poy,Dan L. Sackett,Kyriacos C. Nicolaou,Tito Fojo +9 more
TL;DR: The unification of taxane, epothilone, and sarcodictyin chemistries in a single pharmacophore provides a framework to study drug-tubulin interactions that should assist in the rational design of agents targeting tubulin.