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Patricia E. Kuwabara
Researcher at University of Bristol
Publications - 22
Citations - 2204
Patricia E. Kuwabara is an academic researcher from University of Bristol. The author has contributed to research in topics: Caenorhabditis elegans & Gene. The author has an hindex of 13, co-authored 21 publications receiving 2074 citations. Previous affiliations of Patricia E. Kuwabara include Wellcome Trust Sanger Institute.
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Journal ArticleDOI
The genome sequence of Caenorhabditis briggsae: A platform for comparative genomics
Lincoln Stein,Zhirong Bao,Zhirong Bao,Darin Blasiar,Thomas Blumenthal,Michael R. Brent,Nansheng Chen,Asif T. Chinwalla,Laura Clarke,Chris Clee,Avril Coghlan,Alan Coulson,Alan Coulson,Peter D'Eustachio,Peter D'Eustachio,David H. A. Fitch,Lucinda Fulton,Robert E Fulton,Sam Griffiths-Jones,Todd W. Harris,LaDeana W. Hillier,LaDeana W. Hillier,Ravi Kamath,Patricia E. Kuwabara,Elaine R. Mardis,Marco A. Marra,Marco A. Marra,Tracie L. Miner,Patrick Minx,James C. Mullikin,James C. Mullikin,Robert W. Plumb,Jane Rogers,Jacqueline E. Schein,Jacqueline E. Schein,Marc Sohrmann,John Spieth,Jason E. Stajich,Chaochun Wei,David Willey,Richard K. Wilson,Richard Durbin,Robert H. Waterston,Robert H. Waterston +43 more
TL;DR: Comparisons of the two genomes exhibit extensive colinearity, and the rate of divergence appears to be higher in the chromosomal arms than in the centers, which will help to understand the evolutionary forces that mold nematode genomes.
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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
Daniele Bergamaschi,Yardena Samuels,Nigel J. O'Neil,Giuseppe Trigiante,Tim Crook,Jung-Kuang Hsieh,Daniel J. O'Connor,Shan Zhong,Isabelle Campargue,Matthew L. Tomlinson,Patricia E. Kuwabara,Xin Lu +11 more
TL;DR: iASPP is an evolutionarily conserved inhibitor of p53; inhibition of iASPP by RNA-mediated interference or antisense RNA in C. elegans or human cells, respectively, induces p53-dependent apoptosis and could provide an important new strategy for treating tumors expressing wild-type p53.
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The sterol-sensing domain: multiple families, a unique role?
TL;DR: How the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis is discussed.
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Negative regulation of male development in Caenorhabditis elegans by a protein–protein interaction between TRA-2A and FEM-3
TL;DR: It is found that excess FEM-3 can overcome the feminizing effect of tra-2 and cause widespread masculinization of XX somatic tissues, and it is shown that the masculinizing effects of excess Fems3 can be suppressed by overproduction of the carboxy-terminal domain of TRA-2A.
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The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans
TL;DR: A global survey of the phenotypes produced by RNAi reveals that these genes do not require Smo for activity and that they function in multiple aspects of C. elegans development, including molting, cytokinesis, growth, and pattern formation.