P
Patrick Aldrin-Kirk
Researcher at Lund University
Publications - 14
Citations - 1107
Patrick Aldrin-Kirk is an academic researcher from Lund University. The author has contributed to research in topics: Capsid & Embryonic stem cell. The author has an hindex of 8, co-authored 13 publications receiving 810 citations. Previous affiliations of Patrick Aldrin-Kirk include University of Copenhagen.
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Journal ArticleDOI
Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
Staffan Holmqvist,Oldriska Chutna,Luc Bousset,Patrick Aldrin-Kirk,Wen Li,Tomas Björklund,Zhan-You Wang,Laurent Roybon,Ronald Melki,Jia-Yi Li,Jia-Yi Li +10 more
TL;DR: The first experimental evidence that different α-synuclein forms can propagate from the gut to the brain is provided, and that microtubule-associated transport is involved in the translocation of aggregated α- synuclein in neurons is provided.
Journal ArticleDOI
Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient.
Pedro Rifes,Marc Isaksson,Gaurav Singh Rathore,Patrick Aldrin-Kirk,Oliver Knights Møller,Guido Barzaghi,Julie Lee,Kristoffer L. Egerod,Dylan M. Rausch,Malin Parmar,Tune H. Pers,Thomas Laurell,Agnete Kirkeby +12 more
TL;DR: The approach, named microfluidic-controlled stem cell regionalization (MiSTR), exposes pluripotent stem cells to signaling gradients that mimic developmental patterning, and will facilitate research on the factors and processes underlying rostro-caudal neural tube patterning.
Journal ArticleDOI
A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism.
Marcus Davidsson,Gang Wang,Patrick Aldrin-Kirk,Tiago Cardoso,Sara Nolbrant,Morgan Hartnor,Janitha Mudannayake,Malin Parmar,Tomas Björklund +8 more
TL;DR: It is shown that such viruses can be designed to target human dopamine neurons in vivo and to transport along the connective pathways in the brain, allowing for unprecedented accuracy of the therapy.
Journal ArticleDOI
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency
Julie Tordo,Claire O'Leary,André S L M Antunes,Nuria Palomar,Patrick Aldrin-Kirk,Mark Basche,Antonette Bennett,Zelpha D'Souza,Hélène F.E. Gleitz,Annie Godwin,Rebecca J. Holley,Helen Parker,Ai Yin Liao,Paul Rouse,Amir Saam Youshani,Larbi Dridi,Carla Martins,Thierry Levade,Kevin B. Stacey,Daniel M. Davis,Adam Dyer,Nathalie Clement,Tomas Björklund,Robin R. Ali,Mavis Agbandje-McKenna,Ahad A. Rahim,Alexey V. Pshezhetsky,Simon N. Waddington,Simon N. Waddington,R. Michael Linden,Brian W. Bigger,Els Henckaerts +31 more
TL;DR: A novel AAV gene therapy vector, AAV-TT, is presented, which exceeds the current benchmark neurotropic serotypes AAV9 and AAVrh10 and enables unprecedented correction of a lysosomal transmembrane enzyme deficiency.
Journal ArticleDOI
DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor
Patrick Aldrin-Kirk,Andreas Heuer,Gang Wang,Bengt Mattsson,Martin Lundblad,Malin Parmar,Tomas Björklund +6 more
TL;DR: It is shown that exclusive activation of a cAMP-linked (Gs-coupled) DREADD or serotonin 5-HT6 receptor, located on the grafted DA neurons, is sufficient to induce GIDs in transplanted PD patients.