P
Patrick C. Y. Woo
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 621
Citations - 37320
Patrick C. Y. Woo is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Coronavirus & Gene. The author has an hindex of 85, co-authored 593 publications receiving 31877 citations. Previous affiliations of Patrick C. Y. Woo include The Chinese University of Hong Kong & Kwong Wah Hospital.
Papers
More filters
Journal ArticleDOI
Comparative Analysis of Twelve Genomes of Three Novel Group 2c and Group 2d Coronaviruses Reveals Unique Group and Subgroup Features
Patrick C. Y. Woo,Ming Wang,Susanna K. P. Lau,Huifang Xu,Rosana W.S. Poon,Rongtong Guo,Beatrice H.L. Wong,Kai Gao,Hoi-Wah Tsoi,Yi Huang,Kenneth S. M. Li,Carol S. F. Lam,Kwok-Hung Chan,Bo-Jian Zheng,Kwok-Yung Yuen +14 more
TL;DR: The high Ka/Ks ratio of NS7a and NS7b in bat-CoV HKU9 implies that these two group 2d-specific genes are under high selective pressure and hence are rapidly evolving, and the four subgroups of group 2 coronavirus probably originated from a common ancestor.
Journal ArticleDOI
Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26.
Qihui Wang,Jianxun Qi,Yuan Yuan,Yifang Xuan,Pengcheng Han,Yuhua Wan,Wei Ji,Yan Li,Ying Wu,Jianwei Wang,Aikichi Iwamoto,Patrick C. Y. Woo,Kwok-Yung Yuen,Jinghua Yan,Guangwen Lu,George F. Gao +15 more
TL;DR: These findings support a bat origin for MERS-CoV and indicate the need for surveillance of HKU4-related viruses in bats.
Journal ArticleDOI
Ecoepidemiology and Complete Genome Comparison of Different Strains of Severe Acute Respiratory Syndrome-Related Rhinolophus Bat Coronavirus in China Reveal Bats as a Reservoir for Acute, Self-Limiting Infection That Allows Recombination Events
Susanna K. P. Lau,Kenneth S. M. Li,Yi Huang,Chung Tong Shek,Herman Tse,Ming Wang,Garnet K. Y. Choi,Huifang Xu,Carol S. F. Lam,Rongtong Guo,Kwok-Hung Chan,Bo-Jian Zheng,Patrick C. Y. Woo,Kwok-Yung Yuen +13 more
TL;DR: The present data suggest that SARSr-Rh-BatCoV causes acute, self-limiting infection in horseshoe bats, which serve as a reservoir for recombination between strains from different geographical locations within reachable foraging range.
Journal ArticleDOI
Viral loads in clinical specimens and SARS manifestations.
Ivan Hung,Vincent C.C. Cheng,Alan K.L. Wu,Bone S.F. Tang,Kwok-Hung Chan,Chung-Ming Chu,M.M.L. Wong,W.T. Hui,Leo L.M. Poon,Doris M.W. Tse,Kin Sang Chan,Patrick C. Y. Woo,Susanna K. P. Lau,Joseph S. M. Peiris,Kwok-Yung Yuen +14 more
TL;DR: The number of anatomical sites with detectable viral loads by RT-qPCR appeared to correlate with death risk.
Journal ArticleDOI
Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus
Susanna K. P. Lau,Kenneth S. M. Li,Alan K.L. Tsang,Carol S. F. Lam,Shakeel Ahmed,Honglin Chen,Kwok-Hung Chan,Patrick C. Y. Woo,Kwok-Yung Yuen +8 more
TL;DR: Although MERS-CoV may have diverged from potential lineage C betacoronaviruses in European bats more recently, these bat viruses were unlikely to be the direct ancestor of Meredia respiratory syndrome coronavirus.