P
Peter G. Schultz
Researcher at Scripps Research Institute
Publications - 901
Citations - 96321
Peter G. Schultz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Transfer RNA. The author has an hindex of 156, co-authored 893 publications receiving 89716 citations. Previous affiliations of Peter G. Schultz include Novartis Foundation & University of California, Berkeley.
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An archaebacteria‐derived glutamyl‐tRNA synthetase and tRNA pair for unnatural amino acid mutagenesis of proteins in Escherichia coli
TL;DR: Development of the glutamic acid orthogonal pair increases the potential diversity of unnatural amino acid structures that may be incorporated into proteins in E.coli.
Journal ArticleDOI
Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors.
Ge Zhang,Vadim Baidin,Karanbir S. Pahil,Eileen Moison,David Tomasek,Nitya S. Ramadoss,Arnab Chatterjee,Case W. McNamara,Travis S. Young,Peter G. Schultz,Timothy C. Meredith,Timothy C. Meredith,Daniel Kahne +12 more
TL;DR: A cell-based screen that identifies inhibitors of LPS biosynthesis and transport by exploiting the nonessentiality of this pathway in Acinetobacter, and validates MsbA as an antibacterial target.
Journal ArticleDOI
Mutational Analysis of Backbone Hydrogen Bonds in Staphylococcal Nuclease
Patent
Unnatural reactive amino acid genetic code additions
TL;DR: In this article, the authors provide compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells, such as orthogonal tRNAs, orthogonality, aminoacyl-tRNAsynthetases and unnatural amino acids.
Incorporation of Fluorotyrosines into Ribonucleotide Reductase Using an Evolved, Polyspecific Aminoacyl-tRNA Synthetase
TL;DR: In this paper, the authors presented the directed evolution of aminoacyl-tRNA synthetases (aaRSs) for 2,3,5-trifluorotyrosine (FnYs) and demonstrated their ability to charge an orthogonal tRNA with a series of FnYs while maintaining high specificity over Y.