P
Peter G. Schultz
Researcher at Scripps Research Institute
Publications - 901
Citations - 96321
Peter G. Schultz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Transfer RNA. The author has an hindex of 156, co-authored 893 publications receiving 89716 citations. Previous affiliations of Peter G. Schultz include Novartis Foundation & University of California, Berkeley.
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Journal ArticleDOI
In vivo photocrosslinking with unnatural amino Acid mutagenesis.
Jason W. Chin,Peter G. Schultz +1 more
TL;DR: This work has demonstrated that addition of new components to the translational machinery of Escherichia coli allows several additional amino acids to be site-specifically incorporated into proteins in vivo with high translational fidelity and efficiency in response to the amber codon, TAG.
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High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase
Tsuyoshi Hirota,Jae Wook Lee,Jae Wook Lee,Warren G. Lewis,Warren G. Lewis,Eric E. Zhang,Eric E. Zhang,Ghislain Breton,Xianzhong Liu,Michael Garcia,Eric C. Peters,Jean-Pierre Etchegaray,David Traver,Peter G. Schultz,Peter G. Schultz,Steve A. Kay +15 more
TL;DR: A novel compound “longdaysin” was found to dramatically slow down the speed of the circadian clock through simultaneous inhibition of protein kinases CKIδ, CKIα, and ERK2.
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Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.
TL;DR: Results demonstrate that purmorphamine is a small molecule agonist of Hedgehog signaling, and it may ultimately be useful in the treatment of bone-related disease and neurodegenerative disease.
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Structure of a Copper-Mediated Base Pair in DNA
TL;DR: This work has solved the crystal structure of a duplex containing the metallo-base pair and provides a structural explanation for the B- to Z-DNA transition in this duplex.
Journal ArticleDOI
The Immunological Evolution of Catalysis
Phillip A. Patten,Nathanael S. Gray,Priscilla L. Yang,Cara B. Marks,Gary J. Wedemayer,J. Jay Boniface,Raymond C. Stevens,Peter G. Schultz +7 more
TL;DR: The crystal structure and analysis of somatic and directed active site mutants underscore the role of transition state stabilization in the evolution of this catalytic antibody.