P
Peter G. Schultz
Researcher at Scripps Research Institute
Publications - 901
Citations - 96321
Peter G. Schultz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Transfer RNA. The author has an hindex of 156, co-authored 893 publications receiving 89716 citations. Previous affiliations of Peter G. Schultz include Novartis Foundation & University of California, Berkeley.
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Journal ArticleDOI
From molecular diversity to catalysis : lessons from the immune system
TL;DR: The ability to rationally direct the immune response to generate selective catalysts for reactions ranging from pericyclic and redox reactions to cationic rearrangement reactions underscores the chemical potential of this and other large combinatorial libraries.
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Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
Scott A. Lesley,Peter Kuhn,Adam Godzik,Ashley M. Deacon,I.I. Mathews,Andreas Kreusch,Glen Spraggon,Heath E. Klock,Daniel McMullan,Tanya Shin,Juli Vincent,Alyssa Robb,Linda S. Brinen,M. Miller,Timothy M. McPhillips,Mark A. Miller,Daniel Scheibe,Jaume M. Canaves,Chittibabu Guda,Lukasz Jaroszewski,Thomas L. Selby,Marc-André Elsliger,John Wooley,Susan S. Taylor,Keith O. Hodgson,Ian A. Wilson,Peter G. Schultz,Raymond C. Stevens +27 more
TL;DR: The design and implementation of a high-throughput structural genomics pipeline and its application to the proteome of the thermophilic bacterium Thermotoga maritima is described and successfully cloned and attempted expression of 1,376 of the predicted 1,877 genes.
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Oxysterols direct immune cell migration via EBI2
Sébastien Hannedouche,Juan Zhang,Tangsheng Yi,Weijun Shen,Weijun Shen,Deborah Nguyen,João Pereira,Danilo Guerini,Birgit Baumgarten,Silvio Roggo,Ben Wen,Richard Knochenmuss,Sophie Noël,François Gessier,Lisa M. Kelly,Miroslava Vanek,Stephane Laurent,Inga Preuss,Charlotte Miault,Isabelle Christen,Ratnaningrum Karuna,Wei Li,Dong-In Koo,Thomas Suply,Christian Schmedt,Eric C. Peters,Rocco Falchetto,Andreas Katopodis,Carsten Spanka,Marie-Odile Roy,Michel Detheux,Yu Chen,Peter G. Schultz,Charles Y. Cho,Klaus Seuwen,Jason G. Cyster,Andreas W. Sailer +36 more
TL;DR: The identification of 7α,25-dihydroxycholesterol as a potent and selective agonist of EBI2 and its role in the adaptive immune response is described.
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Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
Costas A. Lyssiotis,Ruth K. Foreman,Judith Staerk,Michael Garcia,Divya Mathur,Styliani Markoulaki,Jacob H. Hanna,Luke L. Lairson,Bradley D. Charette,Laure C. Bouchez,Michael J. Bollong,Conrad Kunick,Achim Brinker,Charles Y. Cho,Peter G. Schultz,Rudolf Jaenisch +15 more
TL;DR: A small-molecule screening platform applied to identify compounds that functionally replace the reprogramming factor Klf4 gave rise to iPS cells that are indistinguishable from murine embryonic stem cells, and can be used to screen large chemical libraries in search of novel compounds to replace theReprogramming factors that induce pluripotency.
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A Novel Copper-Mediated DNA Base Pair
TL;DR: A new strategy which is based on the metaldependent pairing of two nucleobases is described which would allow the replication of DNA containing novel functional groups and lead to novel polymers with interesting chemical and physical properties.