P
Peter G. Schultz
Researcher at Scripps Research Institute
Publications - 901
Citations - 96321
Peter G. Schultz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Transfer RNA. The author has an hindex of 156, co-authored 893 publications receiving 89716 citations. Previous affiliations of Peter G. Schultz include Novartis Foundation & University of California, Berkeley.
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Journal ArticleDOI
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.
Nobutaka Kato,Tomoyo Sakata,Ghislain Breton,Karine G. Le Roch,Advait Nagle,Carsten B Andersen,Badry Bursulaya,Kerstin Henson,Kerstin Henson,Jeffrey R. Johnson,Kota Arun Kumar,Felix Marr,Daniel E. Mason,Case W. McNamara,David Plouffe,Vandana Ramachandran,Muriel Spooner,Tove Tuntland,Yingyao Zhou,Eric C. Peters,Arnab K. Chatterjee,Peter G. Schultz,Peter G. Schultz,Gary E. Ward,Nathanael S. Gray,Jeffrey F. Harper,Elizabeth A. Winzeler,Elizabeth A. Winzeler +27 more
TL;DR: A targeted gene-disruption approach demonstrated that pfcdpk1 seems to be essential for parasite viability, and an in vitro biochemical screen using recombinant PfCDPK1 against a library of 20,000 compounds resulted in the identification of a series of structurally related 2,6,9-trisubstituted purines.
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Versatile strategy for controlling the specificity and activity of engineered T cells.
Jennifer S. Y. Ma,Ji Young Kim,Stephanie A. Kazane,Sei-hyun Choi,Hwayoung Yun,Min Soo Kim,David T. Rodgers,Holly Pugh,Oded Singer,Sophie B. Sun,Bryan R. Fonslow,James N. Kochenderfer,Timothy M. Wright,Peter G. Schultz,Travis S. Young,Chan Hyuk Kim,Yu Cao +16 more
TL;DR: It is demonstrated that a switch-mediated CAR-T approach enables the titration of engineered T-cell antitumor activity, which was observed to be highly advantageous in reducing treatment-related toxicities in vivo.
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Efficient pd-catalyzed amination of heteroaryl halides.
TL;DR: The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands, but the first couplings of amines with chloro- and bromoindoles bearing a free NH are reported.
Journal ArticleDOI
Site-Directed Mutagenesis with an Expanded Genetic Code
TL;DR: A biosynthetic method has been developed that makes possible the site-specific incorporation of a large number of amino acids and analogues within proteins to address detailed structure-function questions.