P
Peter G. Schultz
Researcher at Scripps Research Institute
Publications - 901
Citations - 96321
Peter G. Schultz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Transfer RNA. The author has an hindex of 156, co-authored 893 publications receiving 89716 citations. Previous affiliations of Peter G. Schultz include Novartis Foundation & University of California, Berkeley.
Papers
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Journal ArticleDOI
A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer
Natasha C. Lucki,Genaro R. Villa,Genaro R. Villa,Naja Vergani,Michael J. Bollong,Brittney A. Beyer,Jae Wook Lee,Jae Wook Lee,Justin L. Anglin,Stephan H. Spangenberg,Emily N. Chin,Amandeep Sharma,Kevin Johnson,Philipp N. Sander,Perry Gordon,Stephen Skirboll,Heiko Wurdak,Peter G. Schultz,Paul S. Mischel,Luke L. Lairson +19 more
TL;DR: The identification of a small molecule, termed RIPGBM, from a cell-based chemical screen that selectively induces apoptosis in multiple primary patient-derived GBM CSC cultures is reported, which could provide an approach to the development of treatments for this devastating disease.
Patent
Conjugated polypeptides and methods for their preparation and use.
TL;DR: In this paper, a method for preparing polypeptides having active functionalities proximate their binding sites comprises combining the polypeptic specific for the target ligand with an affinity label including ligand having a reactive group attached thereto.
Journal ArticleDOI
An antibody-catalyzed cis-trans isomerization reaction
Journal ArticleDOI
Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins
Weimin Xuan,Daniel Collins,Minseob Koh,Sida Shao,Anzhi Yao,Han Xiao,Philip Garner,Peter G. Schultz +7 more
TL;DR: This work genetically encoded a thioester-activated aspartic acid (ThioD) in bacteria in good yield and with high fidelity using an orthogonal nonsense suppressor tRNA/aminoacyl-tRNA synthetase (aaRS) pair.
Journal ArticleDOI
Multifunctional Antibody Agonists Targeting Glucagon‐like Peptide‐1, Glucagon, and Glucose‐Dependent Insulinotropic Polypeptide Receptors
Ying Wang,Jintang Du,Huafei Zou,Yan Liu,Yuhan Zhang,Jose Gonzalez,Elizabeth Chao,Lucy Lu,Peng-Yu Yang,Holly Parker,Van Nguyen-Tran,Weijun Shen,Danling Wang,Peter G. Schultz,Feng Wang +14 more
TL;DR: A novel approach to the generation of multifunctional antibody agonists that activate these receptors has been developed and both the mono agonist and dual agonist antibodies both exhibit potent effects on glucose control and body weight reduction in mice.