P
Peter G. Schultz
Researcher at Scripps Research Institute
Publications - 901
Citations - 96321
Peter G. Schultz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Transfer RNA. The author has an hindex of 156, co-authored 893 publications receiving 89716 citations. Previous affiliations of Peter G. Schultz include Novartis Foundation & University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
Rational Design of a Humanized Glucagon-Like Peptide-1 Receptor Agonist Antibody
Yong Zhang,Huafei Zou,Ying Wang,Dawna Caballero,Jose Gonzalez,Elizabeth Chao,Gus Welzel,Weijun Shen,Danling Wang,Peter G. Schultz,Feng Wang +10 more
TL;DR: This work has generated a humanized glucagon-like peptide-1 (GLP-1) receptor agonist antibody by first introducing a coiled-coil "stalk" into CDR3H of the antibody herceptin, which has an extended plasma half-life of approximately four days and sustained control of blood glucose levels for more than a week in mice.
Journal ArticleDOI
Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1
TL;DR: The results demonstrate that antibodies can catalyze conformational changes in protein structure, a transformation involved in many cellular processes.
Journal ArticleDOI
The scope of antibody catalysis
TL;DR: These experiments have demonstrated the chemical potential of large combinatorial libraries that have been given appropriate mechanistic instruction and resulted in antibodies that catalyze reactions by increasingly complex mechanisms.
Sulfonamido 2 arylbenzoxazole GroEL/ES inhibitors are potent antibacterials against methicillin resistant Staphylococcus aureus (MRSA)
Sanofar Abdeen,Trent Kunkle,Nilshad Salim,Anne-Marie Ray,Najiba Mammadova,Corey M. Summers,Mckayla Stevens,Andrew J. Ambrose,Yangshin Park,Peter G. Schultz,Arthur L. Horwich,Quyen Q. Hoang,Eli Chapman,Steven M. Johnson +13 more
Journal ArticleDOI
Transcriptional Effects of the Potent Enediyne Anti-Cancer Agent Calicheamicin γ1I
TL;DR: With longer calicheamicin exposure, genes involved in chromatin arrangement, DNA repair and/or oxidative damage, DNA synthesis and cell cycle checkpoint control as well as other nuclear proteins were all differentially expressed.