P
Peter G. Schultz
Researcher at Scripps Research Institute
Publications - 901
Citations - 96321
Peter G. Schultz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Transfer RNA. The author has an hindex of 156, co-authored 893 publications receiving 89716 citations. Previous affiliations of Peter G. Schultz include Novartis Foundation & University of California, Berkeley.
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Journal ArticleDOI
A New Strategy for the Synthesis of Glycoproteins
Zhiwen Zhang,Jeff Gildersleeve,Yu-Ying Yang,Ran Xu,Joseph A. Loo,Sean Uryu,Chi-Huey Wong,Peter G. Schultz +7 more
TL;DR: An approach to the cotranslational synthesis of selectively glycosylated proteins in which the modified amino acid is genetically encoded is reported, showing that myoglobin containing β–N-acetylglucosamine–serine at a defined position can be expressed in Escherichia coli in good yield and with high fidelity.
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A genetically encoded fluorescent probe in mammalian cells
TL;DR: The small size of Anap, its environment-sensitive fluorescence, and the ability to introduce Anap at specific sites in the proteome by simple mutagenesis make it a unique and valuable tool in eukaryotic cell biology.
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A New Functional Suppressor tRNA/ Aminoacyl-tRNA Synthetase Pair for the in Vivo Incorporation of Unnatural Amino Acids into Proteins
TL;DR: This approach involves the generation of a suppressor tRNA/aminoacyl-tRNA synthetase (tRNACUA/aaRS) pair that is orthogonal to Escherichia coli endogenous tRNAs and insights into the development of additional pairs are provided.
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Enthalpy arrays
Francisco E. Torres,Peter Kuhn,Dirk De Bruyker,Alan G. Bell,Michal V. Wolkin,Eric Peeters,James R. Williamson,Gregory B. Anderson,Gregory P. Schmitz,Michael I. Recht,Sandra Schweizer,Lincoln G. Scott,Jackson Ho,Scott A. Elrod,Peter G. Schultz,Richard A. Lerner,Richard H. Bruce +16 more
TL;DR: The utility of the enthalpy arrays is demonstrated by showing measurements for two protein-ligand binding interactions, phosphorylation of glucose by hexokinase, and respiration of mitochondria in the presence of 2,4-dinitrophenol uncoupler.
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Synthesis of bispecific antibodies using genetically encoded unnatural amino acids.
Chan Hyuk Kim,Jun Y. Axup,Anna Dubrovska,Stephanie A. Kazane,Benjamin M. Hutchins,Erik D. Wold,Vaughn V. Smider,Peter G. Schultz +7 more
TL;DR: An anti-HER2/anti-CD3 bispecific antibody is synthesized, which efficiently cross-linked HER2+ cells and CD3+ cells, and in vitro effector-cell mediated cytotoxicity was observed at picomolar concentrations.