P
Peter G. Schultz
Researcher at Scripps Research Institute
Publications - 901
Citations - 96321
Peter G. Schultz is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Transfer RNA. The author has an hindex of 156, co-authored 893 publications receiving 89716 citations. Previous affiliations of Peter G. Schultz include Novartis Foundation & University of California, Berkeley.
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Journal ArticleDOI
Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach.
TL;DR: It is shown that regional differences in gene expression exist in the heart and common pathways that are coregulated in both models exist, and these might be central to the hypertrophic phenotype regardless of the initial hypertrophic stimuli.
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Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase.
TL;DR: The crystal structure of an evolved aminoacyl-tRNA synthetase that charges the unnatural amino acid p-acetylphenylalanine is described.
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Trapping a transition state in a computationally designed protein bottle
Aaron D. Pearson,Jeremy H. Mills,Yifan Song,Fariborz Nasertorabi,Gye Won Han,David Baker,Raymond C. Stevens,Peter G. Schultz +7 more
TL;DR: A protein is identified in which the side chain of p-biphenylalanine is trapped in the energetically disfavored, coplanar conformation of the TS of the bond rotation reaction.
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Design of Potent and Proteolytically Stable Oxyntomodulin Analogs.
Avinash Muppidi,Avinash Muppidi,Huafei Zou,Peng-Yu Yang,Elizabeth Chao,Lance Sherwood,Vanessa Núñez,Ashley K. Woods,Peter G. Schultz,Peter G. Schultz,Qing Lin,Weijun Shen +11 more
TL;DR: A new class of cross-linked OXM analogs are reported that show increased plasma stability and higher potency in activating both GLP-1R and GCGR, and the extended in vivo half-life results in superior antihyperglycemic activity in mice compared to the wild-type OXM.
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Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA)
Sanofar Abdeen,Trent Kunkle,Nilshad Salim,Anne-Marie Ray,Najiba Mammadova,Corey M. Summers,Mckayla Stevens,Andrew J. Ambrose,Yangshin Park,Peter G. Schultz,Arthur L. Horwich,Quyen Q. Hoang,Eli Chapman,Steven M. Johnson +13 more
TL;DR: The antibiotic effects of asymmetric analogs of this scaffold against a panel of bacteria known as the ESKAPE pathogens, where many analogs were potent inhibitors of E. faecium and S. aureus proliferation, are reported.