P
Peter M. Rothwell
Researcher at University of Oxford
Publications - 815
Citations - 77220
Peter M. Rothwell is an academic researcher from University of Oxford. The author has contributed to research in topics: Stroke & Population. The author has an hindex of 134, co-authored 779 publications receiving 67382 citations. Previous affiliations of Peter M. Rothwell include Leicester Royal Infirmary & University of Edinburgh.
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External validity of randomised controlled trials: “To whom do the results of this trial apply?”
TL;DR: In this paper, the authors present a checklist for clinicians to consider external validity in the design and reporting of RCTs and make recommendations for greater consideration of external validity for clinical trials.
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Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension.
Peter M. Rothwell,Sally C Howard,Eamon Dolan,Eoin O'Brien,Joanna Dobson,Björn Dahlöf,Peter S. Sever,Neil R Poulter +7 more
TL;DR: Visit-to-visit variability in systolic blood pressure (SBP) and maximum SBP are strong predictors of stroke, independent of mean SBP.
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Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials
Katayoun Vahedi,Jeannette Hofmeijer,Eric Juettler,Eric Vicaut,Bernard George,Ale Algra,G Johan Amelink,Peter Schmiedeck,Stefan Schwab,Stefan Schwab,Peter M. Rothwell,Marie-Germaine Bousser,H. Bart van der Worp,Werner Hacke +13 more
TL;DR: In patients with malignant MCA infarction, decompressive surgery undertaken within 48 h of stroke onset reduces mortality and increases the number of patients with a favourable functional outcome.
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Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis.
Peter M. Rothwell,Michael Eliasziw,Sergei A. Gutnikov,Allan J. Fox,D W Taylor,Mayberg,Charles Warlow,H. J. M. Barnett +7 more
TL;DR: Re-analysis of the trials with the same measurements and definitions yielded highly consistent results, indicating that surgery is of some benefit for patients with 50-69% symptomatic stenosis, and highly beneficial for those with 70% symptome stenosis or greater but without near-occlusion.
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Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery
TL;DR: Benefit from endarterectomy depends not only on the degree of carotid stenosis, but also on several other clinical characteristics such as delay to surgery after the presenting event, and on the timing of surgery.