Peter S. Nelson

TL;DR: Tissue distribution of RDH12 and its catalytic properties suggest that, in most tissues,RDH12 primarily contributes to the reduction of all-trans-retinaldehyde; however, at saturating concentrations of peroxidic aldehydes in the cells undergoing oxidative stress, for example, photoreceptors, RDH 12 might also play a role in detoxification of lipid peroxidation products.

TL;DR: It is determined that ERG activates the transcriptional program regulated by YAP1 of the Hippo signaling pathway and found that prostate-specific activation of either ERG or Yap1 in mice induces similar transcriptional changes and results in age-related prostate tumors.

TL;DR: Toll receptor proteins in Drosophila are involved in establishing the dorsal‐ventral axis in embryogenesis as well as participating in the innate immune response to invading pathogens, and a better understanding of this response may provide improved therapeutic modalities in the treatment of bacterial and fungal sepsis.

TL;DR: It is indicated that prostate cancers undergo an adaptive response to castration that is associated with the up-regulation of transcripts encoding enzymes involved in the biosynthesis of androgens, and targeting these metabolic enzymes either individually or using combinations of agents to inhibit testicular, adrenal, and intracrine sources may provide enhanced clinical responses.

TL;DR: Pritchard et al. as discussed by the authors found that patients with inherited DNA repair mutations appeared to benefit from standard therapies similarly to the overall population; prospective studies are ongoing to investigate the impact of PARPi/platinum.