P
Peter S. Nelson
Researcher at Fred Hutchinson Cancer Research Center
Publications - 497
Citations - 57568
Peter S. Nelson is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 96, co-authored 425 publications receiving 47923 citations. Previous affiliations of Peter S. Nelson include University of Washington & National Institutes of Health.
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Journal ArticleDOI
Canary Prostate Active Surveillance Study: design of a multi-institutional active surveillance cohort and biorepository.
Lisa F. Newcomb,James D. Brooks,Peter R. Carroll,Ziding Feng,Martin E. Gleave,Peter S. Nelson,Peter S. Nelson,Ian M. Thompson,Daniel W. Lin,Daniel W. Lin +9 more
TL;DR: The Canary Prostate Active Surveillance Study as mentioned in this paper is a multicenter study and a biorepository that will discover and confirm biomarkers of aggressive disease as defined by histologic, prostate-specific antigen, or clinical criteria.
Journal ArticleDOI
Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage
Payel Chatterjee,Michael T. Schweizer,Michael T. Schweizer,Jared M. Lucas,Ilsa Coleman,Michael D. Nyquist,Sander B. Frank,Robin Tharakan,Elahe A. Mostaghel,Elahe A. Mostaghel,Jun Luo,Colin C. Pritchard,Hung-Ming Lam,Eva Corey,Emmanuel S. Antonarakis,Samuel R. Denmeade,Peter S. Nelson,Peter S. Nelson +17 more
TL;DR: The results provide a mechanistic rationale for directing SPA therapy to PCs with AR amplification or DNA repair deficiency, and for combining SPA Therapy with PARP inhibition.
Journal ArticleDOI
Targeted Androgen Pathway Suppression in Localized Prostate Cancer: A Pilot Study
Elahe A. Mostaghel,Peter S. Nelson,Paul H. Lange,Daniel W. Lin,Mary-Ellen Taplin,Steven P. Balk,William J. Ellis,Philip W. Kantoff,Brett T. Marck,Daniel Tamae,Alvin M. Matsumoto,Lawrence D. True,Robert L. Vessella,Trevor M. Penning,Rachel Hunter Merrill,Roman Gulati,Bruce Montgomery +16 more
TL;DR: Tissue-based analysis of steroids and AR signaling is critical to informing the search for optimal local and systemic control of high-risk prostate cancer.
Journal ArticleDOI
Analytic validation of a clinical-grade PTEN immunohistochemistry assay in prostate cancer by comparison with PTEN FISH.
Tamara L. Lotan,Wei Wei,Olga Ludkovski,Carlos L. Morais,Liana B. Guedes,Tamara Jamaspishvili,Karen Lopez,Sarah T. Hawley,Ziding Feng,Ladan Fazli,Antonio Hurtado-Coll,Jesse K. McKenney,Jeff Simko,Peter R. Carroll,Martin E. Gleave,Daniel W. Lin,Peter S. Nelson,Peter S. Nelson,Ian M. Thompson,Lawrence D. True,James D. Brooks,Raymond S. Lance,Dean A. Troyer,Jeremy A. Squire,Jeremy A. Squire +24 more
TL;DR: A clinical-grade, automated, and inexpensive immunohistochemical assay to detect PTEN loss is developed and is a sensitive method for detection of homozygous PTEN gene deletions.
Journal ArticleDOI
Loss of stearoyl‐CoA desaturase expression is a frequent event in prostate carcinoma
Stacy Moore,Beatrice S. Knudsen,Lawrence D. True,Sarah Hawley,Ruth Etzioni,Christian Wade,David Gifford,Ilsa Coleman,Peter S. Nelson +8 more
TL;DR: Results indicate that loss of SCD expression is a frequent event in prostate adenocarcinoma, and further supports a role for altered lipid metabolism as a factor in the process of carcinogenesis.