P
Peter S. Nelson
Researcher at Fred Hutchinson Cancer Research Center
Publications - 497
Citations - 57568
Peter S. Nelson is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 96, co-authored 425 publications receiving 47923 citations. Previous affiliations of Peter S. Nelson include University of Washington & National Institutes of Health.
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Journal Article
Molecular effects of the herbal compound PC-SPES: identification of activity pathways in prostate carcinoma.
TL;DR: CDNA microarray analysis was used to identify gene expression changes in LNCaP prostate carcinoma cells exposed to PC-SPES and estrogenic agents including diethylstilbestrol and suggests that alterations in specific genes involved in modulating the cell cycle, cell structure, and androgen response may be responsible for PC- SPES-mediated cytotoxicity.
Journal Article
PART-1: A Novel Human Prostate-specific, Androgen-regulated Gene that Maps to Chromosome 5q12
Biaoyang Lin,James T. White,Camari Ferguson,Roger E. Bumgarner,Cynthia Friedman,Barbara J. Trask,William J. Ellis,Paul H. Lange,Leroy Hood,Peter S. Nelson +9 more
TL;DR: A novel gene that is identified as a new gene involved in the androgen receptor-regulated gene network of the human prostate that may play a role in the etiology of prostate carcinogenesis is identified.
Journal ArticleDOI
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.
Mirja Rotinen,Sungyong You,Julie Yang,Simon G. Coetzee,Mariana Reis-Sobreiro,Wen-Chin Huang,Wen-Chin Huang,Fangjin Huang,Xinlei Pan,Alberto Yáñez,Dennis J. Hazelett,Chia-Yi Chu,Kenneth Steadman,Colm Morrissey,Peter S. Nelson,Eva Corey,Leland W.K. Chung,Stephen J. Freedland,Dolores Di Vizio,Isla P. Garraway,Ramachandran Murali,Beatrice S. Knudsen,Michael R. Freeman +22 more
TL;DR: It is suggested that OC2 displaces AR-dependent growth and survival mechanisms in many cases where AR remains expressed, but where its activity is bypassed, and is also a potential drug target in the metastatic phase of aggressive PC.
Journal ArticleDOI
Use of Aspirin and Other Nonsteroidal Antiinflammatory Medications in Relation to Prostate Cancer Risk
Claudia A. Salinas,Erika M. Kwon,Liesel M. FitzGerald,Ziding Feng,Peter S. Nelson,Peter S. Nelson,Elaine A. Ostrander,Ulrike Peters,Ulrike Peters,Janet L. Stanford,Janet L. Stanford +10 more
TL;DR: There was no evidence that the association with aspirin use varied by disease aggressiveness, but there was effect modification with a genetic variant in prostaglandin-endoperoxide synthase 2 (PTGS2) (rs12042763).
Journal ArticleDOI
Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells.
Yoshito Kinoshita,Abel D. Jarell,Jean Michel Flaman,Greg Foltz,James M. Schuster,Bryce L. Sopher,Dwain K. Irvin,Kevin C. Kanning,Harley I. Kornblum,Peter S. Nelson,Phil Hieter,Richard S. Morrison +11 more
TL;DR: Yeast strains harboring temperature-sensitive mutations in the pescadillo gene were arrested in either G1 or G2 when grown in nonpermissive conditions, demonstrating that pescADillo is an essential gene in yeast and is required for cell cycle progression.