P
Peter S. Nelson
Researcher at Fred Hutchinson Cancer Research Center
Publications - 497
Citations - 57568
Peter S. Nelson is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 96, co-authored 425 publications receiving 47923 citations. Previous affiliations of Peter S. Nelson include University of Washington & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Understanding Drug Sensitivity and Tackling Resistance in Cancer
Jeffrey W. Tyner,Franziska Haderk,Anbarasu Kumaraswamy,Linda B. Baughn,Brian G Van Ness,Song Liu,Himangi Marathe,Joshi J. Alumkal,Trever G. Bivona,Keith Syson Chan,Brian J. Druker,Alan D. Hutson,Peter S. Nelson,Charles L. Sawyers,Christopher D. Willey +14 more
TL;DR: A framework to understand the types and biological causes of resistance is described, providing translational opportunities to tackle drug resistance by rational therapeutic strategies.
Journal ArticleDOI
Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer
Erolcan Sayar,Radhika Patel,Ilsa Coleman,Martine Roudier,Ailin Zhang,Pallabi Mustafi,Jin Yih Low,B. H. and Hanratty,Lisa S Ang,Vipul Bhatia,Mohamed Adil,Hasim Bakbak,David A. Quigley,Michael T. Schweizer,Jessica Hawley,Lori Kollath,Lawrence D. True,Felix Y. Feng,Neil H. Bander,Eva Corey,John Lee,Colm Morrissey,Roman Gulati,Peter S. Nelson,Michael C. Haffner +24 more
TL;DR: In this article , the authors demonstrate that PSMA expression is heterogeneous across different metastatic sites and molecular subtypes of prostate cancer, and suggest that epigenetic therapies can be used to augment PSMA levels.
Posted ContentDOI
Targeting RET Kinase in Neuroendocrine Prostate Cancer
Halena R. VanDeusen,Johnny R. Ramroop,Katherine L. Morel,Anjali V. Sheahan,Zoi Sychev,Nathan A. Lau,Larry C. Cheng,Victor M. Tan,Zhen Li,Ashley Petersen,John K. Lee,Jung-Wook Park,Rendong Yang,Ilsa Coleman,Owen N. Witte,Colm Morrissey,Eva Corey,Peter S. Nelson,Peter S. Nelson,Leigh Ellis,Leigh Ellis,Justin M. Drake +21 more
TL;DR: The results suggest that targeting RET in NEPC tumors with high RET expression and may be a novel treatment option and provide a novel approach for treating NEPC.
Regulation by Zeb1 and Src Family Kinases
Aaron P. Putzke,Aviva P. Ventura,Alexander M. Bailey,Canan Akture,John Opoku-Ansah,Muge Celiktas,Michael S. Hwang,Douglas S. Darling,Ilsa Coleman,Peter S. Nelson,Holly M. Nguyen,Eva Corey,Muneesh Tewari,Colm Morrissey,Robert L. Vessella,Beatrice S. Knudsen +15 more
TL;DR: Sedata suggest that transcriptional regulation of E-cad-herin differs in cultured cells versus xenografts, which more faithfully reflect E- cadherin regulation in cancers in human beings.