P
Peter S. Nelson
Researcher at Fred Hutchinson Cancer Research Center
Publications - 497
Citations - 57568
Peter S. Nelson is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 96, co-authored 425 publications receiving 47923 citations. Previous affiliations of Peter S. Nelson include University of Washington & National Institutes of Health.
Papers
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Journal ArticleDOI
Patterns of structural variation define prostate cancer across disease states
Meng Zhou,Minjeong Ko,Anna C. H. Hoge,Kelsey Luu,Yuzhen Liu,Magdalena L. Russell,William W. Hannon,Zhenwei Zhang,Jian Carrot-Zhang,Rameen Beroukhim,Eliezer M. Van Allen,Atish D. Choudhury,Peter S. Nelson,Matthew L. Freedman,Mary-Ellen Taplin,Matthew Meyerson,Srinivas R. Viswanathan,Gavin Ha +17 more
TL;DR: This work uniformly characterized structural alterations across 278 localized and 143 metastatic prostate cancers profiled by whole genome and transcriptome sequencing and defined nine subclasses of mCRPC based on signatures of structural variation, each associated with distinct genetic features and clinical outcomes.
Journal ArticleDOI
Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy
Vipul Bhatia,Nikhil V. Kamat,Tiffany E. Pariva,Li-Ting Wu,Annabelle Tsao,Koichi Sasaki,Huiyun Sun,Ilsa Coleman,Ailin Zhang,Dmytro Rudoy,Roman Gulati,Radhika Patel,Martine Roudier,Lawrence D. True,Shivani Srivastava,Colm Morrissey,Michael C. Haffner,Peter S. Nelson,Saul J. Priceman,Jun Ishihara,John Lee +20 more
TL;DR: In this paper , a STEAP1-directed CAR T cell therapy was developed for metastatic prostate cancer using a collagen binding domain (CBD)-IL-12 fusion protein.
Journal ArticleDOI
Cell type-specific analyses for identifying prostate cancer biomarkers
Peter S. Nelson,Bruce Montgomery +1 more
TL;DR: This review describes approaches that use cell type-specific analysis methods to identify cancer-associated features with the potential of distinguishing individuals with cancer of the prostate.
Book ChapterDOI
Transcriptional Profiling of Prostate Cancer: Biomarker Identification and Clinical Applications
Nigel Clegg,Peter S. Nelson +1 more
TL;DR: An overview of the basic technologies associated with gene expression profiling is provided, recent advances in the transcript-based search for prostate cancer biomarkers are described, and future applications of these strategies are discussed in the context of prostate cancer diagnosis and treatment stratification.
Journal ArticleDOI
Heterogeneity and the tumor microenvironment in neuroendocrine prostate cancer.
Lauren Brady,Peter S. Nelson +1 more
TL;DR: Current efforts to better understand the heterogenous landscape of neuroendocrine prostate cancer are discussed and research efforts to define the interplay between tumor cells and the microenvironment are summarized, with an emphasis on the immune component.