P
Peter S. Nelson
Researcher at Fred Hutchinson Cancer Research Center
Publications - 497
Citations - 57568
Peter S. Nelson is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 96, co-authored 425 publications receiving 47923 citations. Previous affiliations of Peter S. Nelson include University of Washington & National Institutes of Health.
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Journal ArticleDOI
Analysis of testosterone and dihydrotestosterone from biological fluids as the oxime derivatives using high‐performance liquid chromatography/tandem mass spectrometry
Thomas F. Kalhorn,Stephanie T. Page,William N. Howald,Elahe A. Mostaghel,Elahe A. Mostaghel,Peter S. Nelson,Peter S. Nelson +6 more
TL;DR: Given its high reproducibility, sensitivity, and relative simplicity, this assay should be of use in determining androgen levels in biospecimens, particularly in settings where sample quantity or steroid concentration are low.
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ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21.
Hao Geng,Brooks L. S. Rademacher,Janét Pittsenbarger,Chung Ying Huang,Christopher T. Harvey,Marie C. Lafortune,Anne Myrthue,Mark Garzotto,Peter S. Nelson,Tomasz M. Beer,David Z. Qian +10 more
TL;DR: Molecular data provide a mechanistic rationale for the observed in vivo clinical association between ID1 upregulation and relapse-free survival and shows that ID1 expression has a novel therapeutic role in prostate cancer chemotherapy and prognosis.
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Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo.
Tom S. Kim,Akiko Maeda,Tadao Maeda,Cynthia Heinlein,Natalia Y. Kedishvili,Krzysztof Palczewski,Peter S. Nelson +6 more
TL;DR: In this article, the role of RDH11 in the retinoid cycle was investigated in mice and showed that it has a measurable role in regenerating the visual pigment by complementing RDH5 as an 11cis-RDH in RPE cells.
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Combined MYC activation and Pten loss are sufficient to create genomic instability and lethal metastatic prostate cancer
Gretchen K. Hubbard,Laura N. Mutton,May Khalili,Ryan P. McMullin,Jessica L. Hicks,Daniella Bianchi-Frias,Lucas A. Horn,Ibrahim Kulac,Michael S. Moubarek,Peter S. Nelson,Srinivasan Yegnasubramanian,Angelo M. De Marzo,Charles J. Bieberich +12 more
TL;DR: Combined MYC activation and Pten loss driven by the Hoxb13 regulatory locus synergize to induce genomic instability and aggressive prostate cancer that phenocopies the human disease at the histologic and genomic levels.
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Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways
Lisly Chéry,Hung-Ming Lam,Ilsa Coleman,Bryce Lakely,Roger Coleman,Sandy Larson,Julio A. Aguirre-Ghiso,Jing Xia,Roman Gulati,Peter S. Nelson,Bruce Montgomery,Paul H. Lange,Linda A. Snyder,Robert L. Vessella,Colm Morrissey +14 more
TL;DR: This study provides the first clinical evidence of the p38 pathway as a potential biomarker for early recurrence and an attractive target for therapeutic intervention in cancer patients.