Petr Dusek

TL;DR: In a prospective multicentre study involving 1280 patients with idiopathic RBD, Postuma et al. test the predictive power of 21 prodromal markers of neurodegeneration, providing a template for planning neuroprotective trials.

TL;DR: Wilson disease (WD) is a potentially treatable, inherited disorder of copper metabolism characterised by pathological copper accumulation as mentioned in this paper, which is caused by mutations in the ATP7B gene, which encodes a transmembrane copper-transporting ATPase, leading to copper overload in the liver, brain and other organs.

TL;DR: In this paper, the authors reviewed available studies concerning Fe, Cu, Fe and Mn in Parkinson's disease and Wilson's disease, and concluded that local dysregulation of iron metabolism in the substantia nigra (SN) seems to be related to neurodegeneration with an increase in SN iron concentration, accompanied by decreased SN Cu and ceruloplasmin concentrations and increased free Cu concentrations and decreased ferroxidase activity in the cerebrospinal fluid.

TL;DR: An update on recent findings related to genetics, pathogenic mechanisms, diagnosis, and treatment of movement disorders associated with dysregulation of brain iron is provided and a new classification of NBIAs is proposed.

TL;DR: An overview of historical developments of research into iron metabolism and its relevance in neurodegenerative disorders is provided and therapeutic results reviewing reports of iron chelation therapy and deep brain stimulation are summarized.