T
Thomas R Barber
Researcher at University of Oxford
Publications - 31
Citations - 1635
Thomas R Barber is an academic researcher from University of Oxford. The author has contributed to research in topics: REM sleep behavior disorder & Parkinson's disease. The author has an hindex of 13, co-authored 27 publications receiving 1023 citations. Previous affiliations of Thomas R Barber include Queen Mary University of London & Northwick Park Hospital.
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Journal ArticleDOI
Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study
Ronald B. Postuma,Alex Iranzo,Michele T.M. Hu,Birgit Högl,Bradley F. Boeve,Raffaele Manni,Wolfgang H. Oertel,Isabelle Arnulf,Luigi Ferini-Strambi,Monica Puligheddu,Elena Antelmi,Valérie Cochen De Cock,Dario Arnaldi,Brit Mollenhauer,Aleksandar Videnovic,Karel Sonka,Ki-Young Jung,Dieter Kunz,Yves Dauvilliers,Federica Provini,Simon J.G. Lewis,Jitka Bušková,Milena Pavlova,Anna Heidbreder,Jacques Montplaisir,Joan Santamaria,Thomas R Barber,Ambra Stefani,Erik K. St. Louis,Michele Terzaghi,Annette Janzen,Smandra Leu-Semenescu,G. Plazzi,Flavio Nobili,Friederike Sixel-Doering,Petr Dusek,Frederik Bes,Pietro Cortelli,Kaylena A. Ehgoetz Martens,Jean-François Gagnon,Carles Gaig,Marco Zucconi,Claudia Trenkwalder,Ziv Gan-Or,Christine Lo,Michal Rolinski,Philip Mahlknecht,Evi Holzknecht,Angel R Boeve,Luke N. Teigen,Gianpaolo Toscano,Geert Mayer,Silvia Morbelli,Benjamin Dawson,Amélie Pelletier +54 more
TL;DR: In a prospective multicentre study involving 1280 patients with idiopathic RBD, Postuma et al. test the predictive power of 21 prodromal markers of neurodegeneration, providing a template for planning neuroprotective trials.
Journal ArticleDOI
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
Calliope A. Dendrou,Adrian Cortes,Adrian Cortes,Lydia Shipman,Hayley G. Evans,Kathrine E. Attfield,Luke Jostins,Thomas R Barber,Gurman Kaur,Subita Balaram Kuttikkatte,Oliver A. Leach,Christiane Desel,Soren L. Faergeman,Soren L. Faergeman,Jane Cheeseman,Matt J. Neville,Matt J. Neville,Stephen Sawcer,Alastair Compston,Adam R. Johnson,Christine Everett,John Bell,Fredrik Karpe,Fredrik Karpe,Mark Ultsch,Charles Eigenbrot,Gil McVean,Lars Fugger,Lars Fugger +28 more
TL;DR: A protective homozygous effect is revealed that defined a signaling optimum between autoimmunity and immunodeficiency and identified TYK2 as a potential drug target for certain common autoimmune disorders.
Journal ArticleDOI
Regenerative potential of silk conduits in repair of peripheral nerve injury in adult rats
Wenlong Huang,Wenlong Huang,R. Begum,Thomas R Barber,V. Ibba,N.C.H. Tee,M. Hussain,Mohammad Arastoo,Q. Yang,Lesley G. Robson,S. Lesage,Tom Gheysens,Nicholas James Vavasour Skaer,David Philip Knight,John V. Priestley +14 more
TL;DR: Results show that Spidrex(®) conduits promote excellent axonal regeneration and function recovery, and may have potential for clinical application.
Journal ArticleDOI
Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder
Thomas R Barber,Michael T. Lawton,Michal Rolinski,Michal Rolinski,Samuel Evetts,Fahd Baig,Claudio Ruffmann,Aimie Gornall,Johannes C. Klein,Christine Lo,Gary Dennis,Oliver Bandmann,Timothy G. Quinnell,Zenobia Zaiwalla,Yoav Ben-Shlomo,Michele T.M. Hu +15 more
TL;DR: RBD is impaired across a range of clinical measures consistent with prodromal PD and suggestive of a more severe nonmotor subtype, and clinical risk stratification has the potential to select higher risk patients for neuroprotective interventions.
Journal ArticleDOI
Developing and validating Parkinson's disease subtypes and their motor and cognitive progression
Michael T. Lawton,Yoav Ben-Shlomo,Margaret T May,Fahd Baig,Thomas R Barber,Johannes C. Klein,Diane M A Swallow,Naveed Malek,Katherine A Grosset,Nin Bajaj,Roger A. Barker,Nigel Williams,David J. Burn,Thomas Foltynie,Huw R. Morris,Nicholas W. Wood,Donald G. Grosset,Michele T.M. Hu +17 more
TL;DR: Four novel clusters are found that replicated well across two independent early PD cohorts and were associated with levodopa response and motor progression rates, which has potential implications for better understanding disease pathophysiology and the relevance of patient stratification in future clinical trials.