P
Philip S. Paress
Researcher at Merck & Co.
Publications - 14
Citations - 3606
Philip S. Paress is an academic researcher from Merck & Co.. The author has contributed to research in topics: Chloride channel & Avermectin. The author has an hindex of 10, co-authored 14 publications receiving 3476 citations.
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Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.
Journal ArticleDOI
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans
Doris F. Cully,Demetrios K. Vassilatis,Ken K. Liu,Philip S. Paress,Lex H.T. Van der Ploeg,James M. Schaeffer,Joseph P. Arena +6 more
TL;DR: The electrophysiological and structural properties of these proteins indicate that they are new members of the ligand-gated ion channel superfamily.
Journal ArticleDOI
Identification of a Drosophila melanogaster Glutamate-gated Chloride Channel Sensitive to the Antiparasitic Agent Avermectin
TL;DR: The pharmacological data support the hypothesis that the DrosGluCl-α channel represents the arthropod H-receptor and an important target for the avermectin class of insecticides.
Journal ArticleDOI
The mechanism of action of avermectins in Caenorhabditis elegans: correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity.
Joseph P. Arena,Ken K. Liu,Philip S. Paress,Easter G. Frazier,Doris F. Cully,Helmut Mrozik,James M. Schaeffer +6 more
TL;DR: It is concluded that avermectins and milbemycins mediate their nematocidal effects on C. elegans via an interaction with a common receptor molecule, glutamate-gated chloride channels.
Journal ArticleDOI
Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin.
TL;DR: The anthelmintic/insecticide compound avermectin increased the response to submaximal concentrations of glutamate, shifted the glutamate concentration-response curve to lower concentrations, and slowed the desensitization of glutamate-sensitive current, proposed to be mediated via the same channel.