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Angélica Liechti
Researcher at University of Lausanne
Publications - 17
Citations - 3718
Angélica Liechti is an academic researcher from University of Lausanne. The author has contributed to research in topics: Transcriptome & Y chromosome. The author has an hindex of 12, co-authored 14 publications receiving 2994 citations. Previous affiliations of Angélica Liechti include Swiss Institute of Bioinformatics.
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Journal ArticleDOI
The evolution of gene expression levels in mammalian organs
David Brawand,Magali Soumillon,Magali Soumillon,Anamaria Necsulea,Anamaria Necsulea,Philippe Julien,Philippe Julien,Gábor Csárdi,Gábor Csárdi,Patrick Harrigan,Manuela Weier,Angélica Liechti,Ayinuer Aximu-Petri,Martin Kircher,Frank W. Albert,Ulrich Zeller,Philipp Khaitovich,Frank Grützner,Sven Bergmann,Sven Bergmann,Rasmus Nielsen,Rasmus Nielsen,Svante Pääbo,Henrik Kaessmann +23 more
TL;DR: It is shown that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation.
Journal ArticleDOI
The evolution of lncRNA repertoires and expression patterns in tetrapods
Anamaria Necsulea,Magali Soumillon,Maria Warnefors,Angélica Liechti,Tasman Daish,Ulrich Zeller,Julie C. Baker,Frank Grützner,Henrik Kaessmann +8 more
TL;DR: It is found that lncRNAs, in particular ancient ones, are in general actively regulated and may function predominantly in embryonic development, and an evolutionarily conserved co-expression network is reconstructed.
Journal ArticleDOI
Origins and functional evolution of Y chromosomes across mammals
Diego Cortez,Ray M. Marín,Deborah Toledo-Flores,Laure Froidevaux,Angélica Liechti,Paul D. Waters,Frank Grützner,Henrik Kaessmann +7 more
TL;DR: Although some genes evolved novel functions through spatial/temporal expression shifts, most Y genes probably endured, at least initially, because of dosage constraints, and show notable conservation of proto-sex chromosome expression patterns.
Journal ArticleDOI
Gene expression across mammalian organ development
Margarida Cardoso-Moreira,Margarida Cardoso-Moreira,Jean Halbert,Delphine Valloton,Britta Velten,C. T. Chen,Yi Shao,Angélica Liechti,Kelly Ascencao,Coralie Rummel,Svetlana Ovchinnikova,Pavel V. Mazin,Pavel V. Mazin,Ioannis Xenarios,Keith Harshman,Matthew Mort,David Neil Cooper,Carmen Sandi,Michael J. Soares,Michael J. Soares,Paula G. Ferreira,Sandra Afonso,Miguel Carneiro,James M. A. Turner,John L. VandeBerg,Amir Fallahshahroudi,Per Jensen,R. Behr,Steven Lisgo,Susan Lindsay,Philipp Khaitovich,Philipp Khaitovich,Philipp Khaitovich,Wolfgang Huber,Julie C. Baker,Simon Anders,Yong Zhang,Henrik Kaessmann +37 more
TL;DR: It is found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase during development.
Journal ArticleDOI
Birth and expression evolution of mammalian microRNA genes
Julien Meunier,Julien Meunier,Frédéric Lemoine,Magali Soumillon,Magali Soumillon,Angélica Liechti,Manuela Weier,Katerina Guschanski,Katerina Guschanski,Haiyang Hu,Philipp Khaitovich,Henrik Kaessmann,Henrik Kaessmann +12 more
TL;DR: The study provides detailed insights into the birth and evolution of mammalian miRNA genes and the associated selective forces, and suggests a high rate of miRNA family turnover in mammals with many newly emerged miRNA families being lost soon after their formation.