Pieter C. Dorrestein

TL;DR: The core set of genes responsible for producing clavulanic acid are proposed, based on analyses of the biosynthetic gene cluster content of the three Streptomyces species, by matching them with the specialized metabolites detected in the current study.

TL;DR: LeuA and -B mediate the post-PKS methyl-rhamnosylation of bafilomycin A1 to leucanicidin and of phenazines to endophenasides, showing surprising promiscuity by tolerating both macrolide and phenazine skeletons as the substrates.

TL;DR: In this article, three different imaging mass spectrometry (IMS) approaches, MALDI, DESI and SIMS, are described and their recent applications in the analysis of natural products.

TL;DR: Tundrenone is a highly oxidized metabolite that incorporates both a modified bicyclic chorismate-derived fragment and a modified lipid tail bearing a β,γ-unsaturated α-hydroxy ketone and its discovery support the idea that additional studies of methane-oxidizing bacteria will reveal new naturally occurring molecular scaffolds and the biosynthetic pathways that produce them.