P
Pieter C. Dorrestein
Researcher at University of Montana
Publications - 526
Citations - 47251
Pieter C. Dorrestein is an academic researcher from University of Montana. The author has contributed to research in topics: Microbiome & Biology. The author has an hindex of 85, co-authored 470 publications receiving 31806 citations. Previous affiliations of Pieter C. Dorrestein include University of California, Santa Cruz & Northern Arizona University.
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Journal ArticleDOI
Deconvolution and Database Search of Complex Tandem Mass Spectra of Intact Proteins A COMBINATORIAL APPROACH
Xiaowen Liu,Yuval Inbar,Pieter C. Dorrestein,Colin Wynne,Nathan Edwards,Puneet Souda,Julian P. Whitelegge,Vineet Bafna,Pavel A. Pevzner +8 more
TL;DR: MS-Deconv, a combinatorial algorithm for spectral deconvolution, is presented, which first generates a large set of candidate isotopomer envelopes for a spectrum, then represents the spectrum as a graph, and finally selects its highest scoring subset of envelopes as a heaviest path in the graph.
Journal ArticleDOI
Learning representations of microbe–metabolite interactions
James T. Morton,Alexander A. Aksenov,Alexander A. Aksenov,Louis-Félix Nothias,Louis-Félix Nothias,James R. Foulds,Robert A. Quinn,Michelle H. Badri,Tami L. Swenson,Marc W. Van Goethem,Trent R. Northen,Trent R. Northen,Yoshiki Vázquez-Baeza,Mingxun Wang,Mingxun Wang,Nicholas A. Bokulich,Aaron Watters,Se Jin Song,Richard Bonneau,Pieter C. Dorrestein,Pieter C. Dorrestein,Rob Knight +21 more
TL;DR: In this paper, the conditional probability that each molecule is present given the presence of a specific microorganism was estimated by using neural networks to infer the interactions between microbially produced metabolites and inflammatory bowel disease.
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Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.
Katherine R. Duncan,Max Crüsemann,Anna Lechner,Anindita Sarkar,Jie Li,Nadine Ziemert,Mingxun Wang,Nuno Bandeira,Bradley S. Moore,Bradley S. Moore,Pieter C. Dorrestein,Paul R. Jensen +11 more
TL;DR: Molecular networking and the new concept of pattern-based genome mining are applied to 35 Salinispora strains to provide a method to simultaneously compare large numbers of complex microbial extracts, which facilitated the identification of media components, known compounds and their derivatives, and new compounds that could be prioritized for structure elucidation.
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Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster.
Jaclyn M. Winter,Michelle C. Moffitt,Emmanuel Zazopoulos,James B. McAlpine,Pieter C. Dorrestein,Bradley S. Moore,Bradley S. Moore +6 more
TL;DR: Heterologous expression of the CNQ-525-based nap biosynthetic cluster in Streptomyces albus produced at least seven napyradiomycins, including the new analog 2-deschloro-2-hydroxy-A80915C, which resulted in the first in vivo verification of vanadium-dependent haloperoxidases.
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Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution.
TL;DR: The structure of oxalate decarboxylase is determined from Bacillus subtilis at 1.75 A resolution in the presence of formate and it is postulate that this domain is responsible for the decar boxylase activity and that Glu333 serves as a proton donor in the production of formates.