Showing papers by "Pietro Tiraboschi published in 2017"
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Newcastle University1, University of Sydney2, Mayo Clinic3, National Institutes of Health4, University of Pennsylvania5, Houston Methodist Hospital6, Veterans Health Administration7, King's College London8, University of Exeter9, Stavanger University Hospital10, Van Andel Institute11, Nagoya University12, Rush University Medical Center13, Harvard University14, Columbia University15, University College London16, University of Barcelona17, University of North Carolina at Chapel Hill18, Thomas Jefferson University19, Cleveland Clinic20, University of Washington21, Khalifa University22, University of California, San Diego23, Stanford University24, University of Strasbourg25, University of Michigan26, United States Department of Veterans Affairs27, University of Chieti-Pescara28
TL;DR: The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade.
Abstract: The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade. The revised DLB consensus criteria now distinguish clearly between clinical features and diagnostic biomarkers, and give guidance about optimal methods to establish and interpret these. Substantial new information has been incorporated about previously reported aspects of DLB, with increased diagnostic weighting given to REM sleep behavior disorder and 123iodine-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. The diagnostic role of other neuroimaging, electrophysiologic, and laboratory investigations is also described. Minor modifications to pathologic methods and criteria are recommended to take account of Alzheimer disease neuropathologic change, to add previously omitted Lewy-related pathology categories, and to include assessments for substantia nigra neuronal loss. Recommendations about clinical management are largely based upon expert opinion since randomized controlled trials in DLB are few. Substantial progress has been made since the previous report in the detection and recognition of DLB as a common and important clinical disorder. During that period it has been incorporated into DSM-5, as major neurocognitive disorder with Lewy bodies. There remains a pressing need to understand the underlying neurobiology and pathophysiology of DLB, to develop and deliver clinical trials with both symptomatic and disease-modifying agents, and to help patients and carers worldwide to inform themselves about the disease, its prognosis, best available treatments, ongoing research, and how to get adequate support.
2,558 citations
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TL;DR: The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers to prepare an Italian large longitudinal cohort of DLB patients to improve clinical management and therapy monitoring.
Abstract: Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients’ reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer’s disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort. The questionnaire surveyed: (1) prevalence and incidence of DLB; (2) clinical assessment; (3) relevance and availability of diagnostic tools; (4) pharmacological management of cognitive, motor, and behavioural disturbances; (5) causes of hospitalization, with specific focus on delirium and its treatment. Overall, 135 centers (23.6 %) contributed to the survey. Overall, 5624 patients with DLB are currently followed by the 135 centers in a year (2042 of them are new patients). The percentage of DLB patients was lower (27 ± 8 %) than that of Alzheimer’s disease and frontotemporal dementia (56 ± 27 %) patients. The majority of the centers (91 %) considered the clinical and neuropsychological assessments as the most relevant procedure for a DLB diagnosis. Nonetheless, most of the centers has availability of magnetic resonance imaging (MRI; 95 %), electroencephalography (EEG; 93 %), and FP-CIT single photon emission-computerized tomography (SPECT; 75 %) scan for clinical applications. It will be, therefore, possible to recruit a large harmonized Italian cohort of DLB patients for future cross-sectional and longitudinal multicenter studies.
12 citations
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TL;DR: 1 Mainous AG, Tanner RJ, Anton SD, Jo A. Grip strength as a Marker of Hypertension and Diabetes in Healthy Weight Adults 2015; Am J Prev Med 2015; 49 (6): 850–858.
Abstract: 1 Mainous AG, Tanner RJ, Anton SD, Jo A. Grip Strength as a Marker of Hypertension and Diabetes in Healthy Weight Adults. Am J Prev Med 2015; 49 (6): 850–858. DOI:10.1016/ j.amepre.2015.05.025. 2 Maslow AL, Sui X, Colabianchi N, Hussey J, Blair SN. Muscular Strength and Incident Hypertension in Normotensive and Prehypertensive Men. Med Sci Sports Exerc 2010; 42 (2): 288–295. DOI:10.1249/MSS.0b013e3181b2f0a4. 3 ChenWL, Peng TC, Sun YS et al. Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly. Medicine (Baltimore) 2015; 94 (32): e1335. DOI:10.1097/MD.0000000000001335. 4 Han K, Park YM, KwonHS et al. Sarcopenia as a determinant of blood pressure in older Koreans: findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008-2010. PLoS One 2014; 9 (1): e86902. DOI:10.1371/journal.pone.0086902. 5 Sampaio RAC, Sewo Sampaio PY, Yamada M et al. Arterial stiffness is associated with low skeletal muscle mass in Japanese community-dwelling older adults. Geriatr Gerontol Int 2014; 14 (Suppl 1): 109–114. DOI:10.1111/ ggi.12206. 6 NHANES. National Health and Nutrition Examination Survey Homepage [internet]. [Cited 2 Aug 2016] Available from: http://www.cdc.gov/nchs/nhanes/. 7 NHANES. NCHS Research Ethics Review Board Approval [internet]. [Cited 4 Aug 2016] Available from: http://www. cdc.gov/nchs/nhanes/irba98.htm. 8 NHANES 1999 2000: Muscle Strength Procedures Manual [internet]. [Cited 30 Aug 2016] Available from: https://www.cdc.gov/nchs/data/nhanes/ms.pdf. 9 NHANES 1999 2000: Blood Pressure Data Documentation, Codebook, and Frequencies [internet]. [Cited 2 Aug 2016] Available from: http://wwwn.cdc.gov/Nchs/Nhanes/ 1999-2000/BPX.htm. 10 Keller K, Engelhardt M. Strength and muscle mass loss with aging process. Age and strength loss. Muscles Ligaments Tendons J 2014; 3 (4): 346–350.