P
Polly Downton
Researcher at University of Manchester
Publications - 16
Citations - 715
Polly Downton is an academic researcher from University of Manchester. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 11 publications receiving 554 citations. Previous affiliations of Polly Downton include Manchester Academic Health Science Centre & University of Warwick.
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Journal ArticleDOI
Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome
Laura Baxter,Sucheta Tripathy,Naveed Ishaque,Nico Boot,Adriana Cabral,Eric Kemen,Marco Thines,Marco Thines,Audrey M. V. Ah-Fong,Ryan G. Anderson,Wole Badejoko,Peter D. Bittner-Eddy,Jeffrey L. Boore,Marcus C. Chibucos,Mary Coates,Paramvir S. Dehal,Kim D. Delehaunty,Suomeng Dong,Suomeng Dong,Polly Downton,Bernard Dumas,Bernard Dumas,Georgina Fabro,Catrina Fronick,Susan I. Fuerstenberg,Lucinda Fulton,Elodie Gaulin,Elodie Gaulin,Francine Govers,Linda Karen Hughes,Sean Humphray,Rays H. Y. Jiang,Rays H. Y. Jiang,Howard S. Judelson,Sophien Kamoun,Kim Kyung,Harold J. G. Meijer,Patrick Minx,Paul Morris,Joanne O. Nelson,Vipa Phuntumart,Dinah Qutob,Anne P. Rehmany,Alejandra Rougon-Cardoso,Peter Ryden,Trudy Torto-Alalibo,David J. Studholme,Yuanchao Wang,Joe Win,Jonathan Wood,Sandra W. Clifton,Jane Rogers,Guido Van den Ackerveken,Jonathan D. G. Jones,John M. McDowell,Jim Beynon,Brett M. Tyler,Brett M. Tyler +57 more
TL;DR: The genome sequence of the oomycete Hyaloperonospora arabidopsidis is reported, an obligate biotroph and natural pathogen of Arabidopsis thaliana, which exhibits dramatic reductions in genes encoding RXLR effectors, proteins associated with zoospore formation and motility, and enzymes for assimilation of inorganic nitrogen and sulfur.
Journal ArticleDOI
Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states
Antony Adamson,Christopher Boddington,Polly Downton,William Rowe,James Bagnall,Connie Lam,Apolinar Maya-Mendoza,Lorraine Schmidt,Claire V. Harper,David G. Spiller,David A. Rand,Dean A. Jackson,Michael R. H. White,Pawel Paszek +13 more
TL;DR: It is reported that single, or well-spaced pulses of TNFα (>100 min apart) give a high probability of NF-κB activation and fewer cells respond to shorter pulse intervals suggesting a heterogeneous refractory state.
Journal ArticleDOI
Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation.
James Bagnall,Christopher Boddington,Hazel England,Ruth Brignall,Polly Downton,Zainab Alsoufi,James Boyd,James Boyd,William Rowe,William Rowe,Alex Bennett,Catherine Walker,Antony Adamson,Nisha M. X. Patel,Ronan O’Cualain,Lorraine Schmidt,David G. Spiller,Dean A. Jackson,Werner Müller,Mark Muldoon,Michael R. H. White,Pawel Paszek +21 more
TL;DR: It is proposed that the highly constrained architecture of tissues enables effective localized propagation of inflammatory cues while avoiding out-of-context responses at longer distances.
Journal ArticleDOI
Temperature regulates NF-κB dynamics and function through timing of A20 transcription.
Claire V. Harper,Dan J. Woodcock,Connie Lam,Manuel Garcia-Albornoz,Antony Adamson,Louise Ashall,William Rowe,Polly Downton,Lorraine Schmidt,Simon West,David G. Spiller,David A. Rand,Michael R. H. White +12 more
TL;DR: It is shown that physiologically relevant temperature changes significantly perturb NF-κB dynamics following TNFα stimulation in single cells and are mediated, at least in part, through the key feedback gene TNFAIP3/A20.
Journal ArticleDOI
Circadian rhythms in adaptive immunity
TL;DR: The depth of knowledge on cell intrinsic clocks within adaptive immune cells and how these cells may be temporally directed by extrinsic rhythmic signals are interrogated, including in diseases associated with adaptive immunity such as multiple sclerosis, asthma and parasitic infection are interrogated.