D
David J. Studholme
Researcher at University of Exeter
Publications - 207
Citations - 12980
David J. Studholme is an academic researcher from University of Exeter. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 47, co-authored 185 publications receiving 11024 citations. Previous affiliations of David J. Studholme include Wellcome Trust Sanger Institute & University of East Anglia.
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Journal ArticleDOI
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.
Brian J. Haas,Sophien Kamoun,Sophien Kamoun,Michael C. Zody,Michael C. Zody,Rays H. Y. Jiang,Rays H. Y. Jiang,Robert E. Handsaker,Liliana M. Cano,Manfred Grabherr,Chinnappa D. Kodira,Chinnappa D. Kodira,Sylvain Raffaele,Trudy Torto-Alalibo,Trudy Torto-Alalibo,Tolga O. Bozkurt,Audrey M. V. Ah-Fong,Lucia Alvarado,Vicky L. Anderson,Miles R. Armstrong,Anna O. Avrova,Laura Baxter,Jim Beynon,Petra C. Boevink,Stephanie R. Bollmann,Jorunn I. B. Bos,Vincent Bulone,Guohong Cai,Cahid Cakir,James C. Carrington,Megan Chawner,Lucio Conti,Stefano Costanzo,Richard Ewan,Noah Fahlgren,Michael A. Fischbach,Johanna Fugelstad,Eleanor M. Gilroy,Sante Gnerre,Pamela J. Green,Laura J. Grenville-Briggs,John Griffith,Niklaus J. Grünwald,Karolyn Horn,Neil R. Horner,Chia-Hui Hu,Edgar Huitema,Dong-Hoon Jeong,Alexandra M. E. Jones,Jonathan D. G. Jones,Richard W. Jones,Elinor K. Karlsson,Sridhara G. Kunjeti,Kurt Lamour,Zhenyu Liu,Li-Jun Ma,Dan MacLean,Marcus C. Chibucos,Hayes McDonald,Jessica McWalters,Harold J. G. Meijer,William Morgan,Paul Morris,Carol A. Munro,Keith O'Neill,Keith O'Neill,Manuel D. Ospina-Giraldo,Andrés Pinzón,Leighton Pritchard,Bernard H Ramsahoye,Qinghu Ren,Silvia Restrepo,Sourav Roy,Ari Sadanandom,Alon Savidor,Sebastian Schornack,David C. Schwartz,Ulrike Schumann,Ben Schwessinger,Lauren Seyer,Ted Sharpe,Cristina Silvar,Jing Song,David J. Studholme,Sean M. Sykes,Marco Thines,Marco Thines,Peter J. I. van de Vondervoort,Vipaporn Phuntumart,Stephan Wawra,R. Weide,Joe Win,Carolyn A. Young,Shiguo Zhou,William E. Fry,Blake C. Meyers,Pieter van West,Jean B. Ristaino,Francine Govers,Paul R. J. Birch,Stephen C. Whisson,Howard S. Judelson,Chad Nusbaum +102 more
TL;DR: The sequence of the P. infestans genome is reported, which at ∼240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates and probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
Journal ArticleDOI
InterPro, progress and status in 2005
Nicola Mulder,Rolf Apweiler,Teresa K. Attwood,Amos Marc Bairoch,Alex Bateman,David Binns,Paul Bradley,Peer Bork,Phillip Bucher,Lorenzo Cerutti,Richard R. Copley,Emmanuel Courcelle,Ujjwal Das,Richard Durbin,Wolfgang Fleischmann,Julian Gough,Daniel H. Haft,Nicola Harte,Nicolas Hulo,Daniel Kahn,Alexander Kanapin,Maria Krestyaninova,David M. Lonsdale,Rodrigo Lopez,Ivica Letunic,Martin Madera,John Maslen,Jennifer McDowall,Alex L. Mitchell,Anastasia N. Nikolskaya,Sandra Orchard,Marco Pagni,Chris P. Ponting,Emmanuel Quevillon,Jeremy D. Selengut,Christian J. A. Sigrist,Ville Silventoinen,David J. Studholme,Robert M. Vaughan,Cathy H. Wu +39 more
TL;DR: InterPro release 8.0 contains 11 007 entries, representing 2573 domains, 8166 families, 201 repeats, 26 active sites, 21 binding sites and 20 post-translational modification sites.
Journal ArticleDOI
miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii
Attila Molnar,Frank Schwach,Frank Schwach,David J. Studholme,Eva C. Thuenemann,David C. Baulcombe +5 more
TL;DR: The unicellular alga Chlamydomonas reinhardtii is shown to contain miRNAs, putative evolutionary precursors of mi RNAs and species of siRNAs resembling those in higher plants, indicating that complex RNA-silencing systems evolved before multicellularity and were a feature of primitive eukaryotic cells.
Journal ArticleDOI
Assessing the performance of the Oxford Nanopore Technologies MinION.
Thomas W Laver,James W. Harrison,Paul O'Neill,Karen Moore,Audrey Farbos,Konrad Paszkiewicz,David J. Studholme +6 more
TL;DR: It is shown that MinION sequence reads can enhance contiguity of de novo assembly when used in conjunction with Illumina MiSeq data, as the first nanopore-based single molecule sequencer available to researchers.
Journal ArticleDOI
Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study.
Katherine A Twohig,Tommy Nyberg,Asad Zaidi,Simon Thelwall,Mary Sinnathamby,Shirin Aliabadi,Shaun R. Seaman,Ross J Harris,Russell Hope,Jamie Lopez-Bernal,Eileen Gallagher,Andre Charlett,Daniela De Angelis,Daniela De Angelis,Anne M. Presanis,Anne M. Presanis,Gavin Dabrera,Cherian Koshy,Amy Ash,Emma L. Wise,Nathan Moore,Matilde Mori,Nick Cortes,Jessica Lynch,Stephen P. Kidd,Derek Fairley,Tanya Curran,James McKenna,Helen Adams,Christophe Fraser,Tanya Golubchik,David Bonsall,Mohammed O Hassan-Ibrahim,Cassandra S Malone,Benjamin J Cogger,Michelle Wantoch,Nicola Reynolds,Ben Warne,Joshua Maksimovic,Karla Spellman,Kathryn McCluggage,Michaela John,Robert Beer,Safiah Afifi,Sian Morgan,Angela Marchbank,Anna Price,Christine Kitchen,Huw Gulliver,Ian Merrick,Joel Southgate,Martyn Guest,Robert J. Munn,Trudy Workman,Thomas R. Connor,William D. Fuller,Catherine Bresner,Luke B Snell,Amita Patel,Themoula Charalampous,Gaia Nebbia,Rahul Batra,Jonathan D. Edgeworth,Samuel Robson,Angela Helen Beckett,David M. Aanensen,Anthony Underwood,Corin Yeats,Khalil Abudahab,Ben Taylor,Mirko Menegazzo,Gemma Clark,Wendy Smith,Manjinder Khakh,Vicki M. Fleming,Michelle Lister,Hannah C. Howson-Wells,Louise Berry,Tim Boswell,Amelia Joseph,Iona Willingham,Carl Jones,Christopher W Holmes,Paul W Bird,Thomas Helmer,Karlie Fallon,Julian Tang,Veena Raviprakash,Sharon Campbell,Nicola Sheriff,Victoria Blakey,Lesley-Anne Williams,Matthew Loose,Nadine Holmes,Christopher I. Moore,Matthew Carlile,Victoria Wright,Fei Sang,Johnny Debebe,Francesc Coll,Adrian W Signell,Gilberto Betancor,Harry D Wilson,Sahar Eldirdiri,Anita Kenyon,Thomas R. A. Davis,Oliver G. Pybus,Louis du Plessis,Alex Zarebski,Jayna Raghwani,Moritz U. G. Kraemer,Sarah François,Stephen W Attwood,Tetyana I. Vasylyeva,Marina Escalera Zamudio,Bernardo Gutierrez,M. Estée Török,William L Hamilton,Ian Goodfellow,Grant Hall,Aminu S Jahun,Yasmin Chaudhry,Myra Hosmillo,Malte L Pinckert,Iliana Georgana,S.E. Moses,Hannah Lowe,Luke Bedford,Jonathan D. Moore,Susanne Stonehouse,Chloe L Fisher,Ali R Awan,John Boyes,Judith Breuer,Kathryn Ann Harris,Julianne R Brown,Divya K. Shah,Laura Atkinson,Jack Cd Lee,Nathaniel Storey,Flavia Flaviani,Adela Alcolea-Medina,Rebecca Williams,Gabrielle Vernet,Michael A Chapman,Lisa J Levett,Judith Heaney,Wendy Chatterton,Monika Pusok,Li Xu-McCrae,Darren Smith,Matthew Bashton,Gregory R Young,Alison Holmes,Paul Randell,Alison Cox,Pinglawathee Madona,Frances Bolt,James I. Price,Siddharth Mookerjee,Manon Ragonnet-Cronin,Fabrícia F. Nascimento,David Jorgensen,Igor Siveroni,Robert Johnson,Olivia Boyd,Lily Geidelberg,Erik M. Volz,Aileen G. Rowan,Graham P. Taylor,Katherine Smollett,Nicholas J. Loman,Joshua Quick,Claire McMurray,Joanne D. Stockton,Samuel M. Nicholls,Will P. M. Rowe,Radoslaw Poplawski,Alan McNally,Rocio Martinez Nunez,Jenifer Mason,Trevor Robinson,Elaine O'Toole,Joanne Watts,Cassie Breen,Angela Cowell,Graciela Sluga,Nicholas W Machin,Shazaad Ahmad,Ryan P George,Fenella D. Halstead,Venkat Sivaprakasam,Wendy Hogsden,Christopher J. R. Illingworth,Christopher Jackson,E. Thomson,James Shepherd,Patawee Asamaphan,Marc Niebel,Kathy Li,Rajiv Shah,Natasha Jesudason,Lily Tong,Alice Broos,Daniel Mair,Jenna Nichols,Stephen Carmichael,Kyriaki Nomikou,Elihu Aranday-Cortes,Natasha Johnson,Igor Starinskij,Ana da Silva Filipe,David Robertson,Richard J. Orton,Joseph Hughes,Sreenu Vattipally,Joshua B Singer,Seema Nickbakhsh,Antony D Hale,Louissa R Macfarlane-Smith,Katherine L Harper,Holli Carden,Yusri Taha,Brendan A I Payne,Shirelle Burton-Fanning,Sheila Waugh,Jennifer Collins,Gary Eltringham,Steven Rushton,Sarah J. O'Brien,Amanda Bradley,Alasdair MacLean,Guy Mollett,Rachel Blacow,Kate Templeton,Martin P McHugh,Rebecca Dewar,Elizabeth Wastenge,Samir Dervisevic,Rachael Stanley,Emma Meader,Lindsay Coupland,Louise Smith,Clive Graham,Edward Barton,Debra Padgett,Garren Scott,Emma Swindells,Jane Greenaway,Andrew J. Nelson,Clare M. McCann,Wen Yew,Monique Andersson,Tim E. A. Peto,Anita Justice,David W Eyre,Derrick W. Crook,Tim J Sloan,Nichola Duckworth,Sarah Walsh,Anoop Chauhan,Sharon Glaysher,Kelly Bicknell,Sarah Wyllie,Scott Elliott,A Lloyd,Robert Impey,Nick Levene,Lynn Monaghan,Declan Bradley,Tim Wyatt,Elias Allara,Clare Pearson,Husam Osman,Andrew Bosworth,Esther Robinson,Peter Muir,Ian B Vipond,Richard Hopes,Hannah M Pymont,Stephanie Hutchings,Martin D. Curran,Surendra Parmar,Angie Lackenby,Tamyo Mbisa,Steven Platt,Shahjahan Miah,David F. Bibby,Carmen F. Manso,Jonathan Hubb,Meera Chand,Mary Ramsay,Daniel Bradshaw,Alicia Thornton,Richard H. Myers,Ulf Schaefer,Natalie Groves,David C. Lee,David J. Williams,Nicholas Ellaby,Ian Harrison,Hassan Hartman,Nikos Manesis,Vineet Patel,Chloe Bishop,Vicki Chalker,Juan Ledesma,Katherine Twohig,Matthew T. G. Holden,Sharif Shaaban,Alec Birchley,Alexander Adams,Alisha Davies,Amy Gaskin,Amy Plimmer,Bree Gatica-Wilcox,Caoimhe McKerr,Catherine Moore,Christopher Williams,David Heyburn,Elen De Lacy,Ember Hilvers,Fatima Downing,Giri Shankar,Hannah Jones,Hibo Asad,Jason Coombes,Joanne Watkins,Johnathan M Evans,Laia Fina,Laura Gifford,Lauren Gilbert,Lee Graham,Malorie Perry,M Morgan,Matthew J. Bull,Michelle Cronin,Nicole Pacchiarini,Noel Craine,Rachel Jones,Robin Howe,Sally Corden,Sara Rey,Sara Kumziene-Summerhayes,S Taylor,Simon Cottrell,Sophie Jones,Sue Edwards,Justin O'Grady,Andrew J. Page,Alison E. Mather,David Baker,Steven Rudder,Alp Aydin,Gemma L. Kay,Alexander J. Trotter,Nabil-Fareed Alikhan,Leonardo de Oliveira Martins,Thanh Le-Viet,Lizzie Meadows,Anna L. Casey,Liz Ratcliffe,David Simpson,Zoltan Molnar,Thomas Thompson,Erwan Acheson,Jane A. H. Masoli,Bridget Knight,Sian Ellard,Cressida Auckland,Christopher I. Jones,Tabitha Mahungu,Dianne Irish-Tavares,Tanzina Haque,Jennifer Hart,Eric Witele,Melisa Louise Fenton,Ashok Dadrah,Amanda Symmonds,Tranprit Saluja,Yann Bourgeois,Garry Scarlett,Katie F. Loveson,Salman Goudarzi,Christopher Fearn,Kate B. Cook,Hannah Dent,Hannah Paul,David G Partridge,Mohammad Raza,Cariad Evans,Kate Johnson,Steven Liggett,Paul Baker,Stephen Bonner,Sarah Essex,Ronan Lyons,Kordo Saeed,Adhyana I K Mahanama,Buddhini Samaraweera,Siona Silveira,Emanuela Pelosi,Eleri Wilson-Davies,Rachel Williams,Mark Kristiansen,Sunando Roy,Charlotte A Williams,Marius Cotic,Nadua Bayzid,Adam P Westhorpe,John C. Hartley,Riaz Jannoo,Helen L Lowe,Angeliki Karamani,Leah Ensell,Jacqui Prieto,Sarah Jeremiah,Dimitris Grammatopoulos,Sarojini Pandey,Lisa Berry,Katie Jones,Alex G. Richter,Andrew D Beggs,Angus I. Best,Benita Percival,Jeremy Mirza,Oliver Megram,Megan Mayhew,Liam Crawford,Fiona Ashcroft,Emma Moles-Garcia,Nicola Cumley,Colin Smith,Giselda Bucca,Andrew Hesketh,Beth Blane,Sophia T Girgis,Danielle Leek,Sushmita Sridhar,Sally Forrest,Claire Cormie,Harmeet K Gill,Joana Dias,Ellen Higginson,Mailis Maes,Jamie Young,Leanne M Kermack,Ravi Gupta,Catherine Ludden,Sharon J. Peacock,Sophie Palmer,Carol Churcher,Nazreen F. Hadjirin,Alessandro M Carabelli,Ellena Brooks,Kim S Smith,Katerina Galai,Georgina M McManus,Christopher Ruis,Rose K Davidson,Andrew Rambaut,Thomas N. Williams,Carlos Balcazar,Michael Gallagher,Áine O'Toole,Stefan Rooke,Verity Hill,Kathleen A. Williamson,Thomas D Stanton,Stephen L. Michell,Claire M Bewshea,Ben Temperton,Michelle L Michelsen,Joanna Warwick-Dugdale,Robin Manley,Audrey Farbos,James W. Harrison,Christine Sambles,David J. Studholme,Aaron R. Jeffries,Leigh M Jackson,Alistair C. Darby,Julian A. Hiscox,Steve Paterson,Miren Iturriza-Gomara,Kathryn A Jackson,Anita Lucaci,Edith Vamos,Margaret Hughes,Lucille Rainbow,Richard Eccles,Charlotte Nelson,Mark Whitehead,Lance Turtle,Sam Haldenby,Richard Gregory,Matthew Gemmell,Claudia Wierzbicki,Hermione J. Webster,Thushan I de Silva,Nikki Smith,Adrienn Angyal,Benjamin B Lindsey,Danielle C. Groves,Luke R. Green,Dennis Wang,Timothy M. Freeman,Matthew Parker,Alexander J Keeley,Paul J. Parsons,Rachel Tucker,Rebecca C H Brown,Matthew Wyles,Max Whiteley,Peijun Zhang,Marta Gallis,Stavroula F Louka,Chrystala Constantinidou,Meera Unnikrishnan,Sascha Ott,Jeffrey K. J. Cheng,Hannah E Bridgewater,Lucy R. Frost,Grace Taylor-Joyce,Richard Stark,Laura Baxter,Mohammad Tauqeer Alam,Paul E Brown,Dinesh Aggarwal,Alberto C Cerda,Tammy V Merrill,Rebekah E Wilson,Patrick McClure,Joseph G. Chappell,Theocharis Tsoleridis,Jonathan K. Ball,David Buck,John A. Todd,Angie Green,Amy Trebes,G MacIntyre-Cockett,Mariateresa de Cesare,Alex Alderton,Roberto Amato,Cristina V. Ariani,Mathew A. Beale,Charlotte Beaver,Katherine L. Bellis,Emma Betteridge,James Bonfield,John Danesh,Matthew J. Dorman,Eleanor Drury,Ben Farr,Luke Foulser,Sónia Gonçalves,Scott Goodwin,Marina Gourtovaia,Ewan M. Harrison,David A. Jackson,Dorota Jamrozy,Ian Johnston,Leanne Kane,Sally Kay,Jon-Paul Keatley,Dominic P. Kwiatkowski,Cordelia Langford,Mara K. N. Lawniczak,Laura Letchford,Rich Livett,Stephanie W. Lo,Inigo Martincorena,Samantha McGuigan,Rachel Nelson,Steve Palmer,Naomi Park,Minal Patel,Liam Prestwood,Christoph Puethe,Michael A. Quail,Shavanthi Rajatileka,Carol Scott,Lesley Shirley,John Sillitoe,Michael Spencer Chapman,Scott Aj Thurston,Gerry Tonkin-Hill,Danni Weldon,Diana Rajan,Iraad Bronner,Louise Aigrain,Nicholas M Redshaw,Stefanie V Lensing,Robert Davies,Andrew Whitwham,Jennifier Liddle,Kevin Lewis,Jaime Tovar-Corona,Steven Leonard,Jillian Durham,Andrew Bassett,Shane McCarthy,Robin J Moll,Keith D. James,Karen Oliver,Alex Makunin,Jeffrey C. Barrett,Rory Gunson +607 more
TL;DR: In this paper, the authors compared the severity of the delta variant compared with the alpha variant by determining the relative risk of hospital attendance outcomes and found that outbreaks of the Delta variant in unvaccinated populations might lead to a greater burden on health-care services than the alpha variants.