Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome
Laura Baxter,Sucheta Tripathy,Naveed Ishaque,Nico Boot,Adriana Cabral,Eric Kemen,Marco Thines,Marco Thines,Audrey M. V. Ah-Fong,Ryan G. Anderson,Wole Badejoko,Peter D. Bittner-Eddy,Jeffrey L. Boore,Marcus C. Chibucos,Mary Coates,Paramvir S. Dehal,Kim D. Delehaunty,Suomeng Dong,Suomeng Dong,Polly Downton,Bernard Dumas,Bernard Dumas,Georgina Fabro,Catrina Fronick,Susan I. Fuerstenberg,Lucinda Fulton,Elodie Gaulin,Elodie Gaulin,Francine Govers,Linda Karen Hughes,Sean Humphray,Rays H. Y. Jiang,Rays H. Y. Jiang,Howard S. Judelson,Sophien Kamoun,Kim Kyung,Harold J. G. Meijer,Patrick Minx,Paul Morris,Joanne O. Nelson,Vipa Phuntumart,Dinah Qutob,Anne P. Rehmany,Alejandra Rougon-Cardoso,Peter Ryden,Trudy Torto-Alalibo,David J. Studholme,Yuanchao Wang,Joe Win,Jonathan Wood,Sandra W. Clifton,Jane Rogers,Guido Van den Ackerveken,Jonathan D. G. Jones,John M. McDowell,Jim Beynon,Brett M. Tyler,Brett M. Tyler +57 more
TLDR
The genome sequence of the oomycete Hyaloperonospora arabidopsidis is reported, an obligate biotroph and natural pathogen of Arabidopsis thaliana, which exhibits dramatic reductions in genes encoding RXLR effectors, proteins associated with zoospore formation and motility, and enzymes for assimilation of inorganic nitrogen and sulfur.Abstract:
Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy.read more
Citations
More filters
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
How do plants achieve immunity? Defence without specialized immune cells
Steven H. Spoel,Xinnian Dong +1 more
TL;DR: Recent developments point towards a multilayered plant innate immune system comprised of self-surveillance, systemic signalling and chromosomal changes that together establish effective immunity.
Journal ArticleDOI
Independently evolved virulence effectors converge onto hubs in a plant immune system network
M. Shahid Mukhtar,Anne-Ruxandra Carvunis,Anne-Ruxandra Carvunis,Matija Dreze,Matija Dreze,Petra Epple,Jens Steinbrenner,Jonathan D. Moore,Murat Tasan,Mary Galli,Tong Hao,Marc T. Nishimura,Samuel J. Pevzner,Susan E. Donovan,Lila Ghamsari,Balaji Santhanam,Viviana Romero,Matthew M. Poulin,Fana Gebreab,Bryan J. Gutierrez,Stanley Tam,Dario Monachello,Mike Boxem,Christopher J. Harbort,Nathan A. McDonald,Lantian Gai,Huaming Chen,Yijian He,Jean Vandenhaute,Frederick P. Roth,David E. Hill,Joseph R. Ecker,Marc Vidal,Jim Beynon,Pascal Braun,Jeffery L. Dangl +35 more
TL;DR: An analysis of protein-protein interactions in Arabidopsis identifies the plant interactome and demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens.
Journal ArticleDOI
Modulation of host immunity by beneficial microbes
TL;DR: The current understanding of how symbiotic and nonsymbiotic beneficial soil microbes modulate the plant immune system is reviewed and the role of local and systemic defense responses in establishing the delicate balance between the two partners is discussed.
Journal ArticleDOI
Genome evolution in filamentous plant pathogens: why bigger can be better
Sylvain Raffaele,Sophien Kamoun +1 more
TL;DR: Cases in which genome plasticity has contributed to the emergence of new virulence traits are illustrated and how genome expansions may have had an impact on the co-evolutionary conflict between these filamentous plant pathogens and their hosts are discussed.
References
More filters
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.
Brian J. Haas,Sophien Kamoun,Sophien Kamoun,Michael C. Zody,Michael C. Zody,Rays H. Y. Jiang,Rays H. Y. Jiang,Robert E. Handsaker,Liliana M. Cano,Manfred Grabherr,Chinnappa D. Kodira,Chinnappa D. Kodira,Sylvain Raffaele,Trudy Torto-Alalibo,Trudy Torto-Alalibo,Tolga O. Bozkurt,Audrey M. V. Ah-Fong,Lucia Alvarado,Vicky L. Anderson,Miles R. Armstrong,Anna O. Avrova,Laura Baxter,Jim Beynon,Petra C. Boevink,Stephanie R. Bollmann,Jorunn I. B. Bos,Vincent Bulone,Guohong Cai,Cahid Cakir,James C. Carrington,Megan Chawner,Lucio Conti,Stefano Costanzo,Richard Ewan,Noah Fahlgren,Michael A. Fischbach,Johanna Fugelstad,Eleanor M. Gilroy,Sante Gnerre,Pamela J. Green,Laura J. Grenville-Briggs,John Griffith,Niklaus J. Grünwald,Karolyn Horn,Neil R. Horner,Chia-Hui Hu,Edgar Huitema,Dong-Hoon Jeong,Alexandra M. E. Jones,Jonathan D. G. Jones,Richard W. Jones,Elinor K. Karlsson,Sridhara G. Kunjeti,Kurt Lamour,Zhenyu Liu,Li-Jun Ma,Dan MacLean,Marcus C. Chibucos,Hayes McDonald,Jessica McWalters,Harold J. G. Meijer,William Morgan,Paul Morris,Carol A. Munro,Keith O'Neill,Keith O'Neill,Manuel D. Ospina-Giraldo,Andrés Pinzón,Leighton Pritchard,Bernard H Ramsahoye,Qinghu Ren,Silvia Restrepo,Sourav Roy,Ari Sadanandom,Alon Savidor,Sebastian Schornack,David C. Schwartz,Ulrike Schumann,Ben Schwessinger,Lauren Seyer,Ted Sharpe,Cristina Silvar,Jing Song,David J. Studholme,Sean M. Sykes,Marco Thines,Marco Thines,Peter J. I. van de Vondervoort,Vipaporn Phuntumart,Stephan Wawra,R. Weide,Joe Win,Carolyn A. Young,Shiguo Zhou,William E. Fry,Blake C. Meyers,Pieter van West,Jean B. Ristaino,Francine Govers,Paul R. J. Birch,Stephen C. Whisson,Howard S. Judelson,Chad Nusbaum +102 more
TL;DR: The sequence of the P. infestans genome is reported, which at ∼240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates and probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
Journal ArticleDOI
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
Jörg Kämper,Regine Kahmann,Michael Bölker,Li-Jun Ma,Thomas Brefort,Barry J. Saville,Barry J. Saville,Flora Banuett,James W. Kronstad,Scott E. Gold,Olaf Müller,Michael H. Perlin,Han A. B. Wösten,Ronald P. de Vries,Jose Ruiz-Herrera,Cristina G. Reynaga-Peña,Karen M. Snetselaar,Michael P. McCann,José Pérez-Martín,Michael Feldbrügge,Christoph W. Basse,Gero Steinberg,José I. Ibeas,William K. Holloman,Plinio Guzmán,Mark L. Farman,Jason E. Stajich,Rafael Sentandreu,Juan Manuel González-Prieto,John C. Kennell,Lazaro Molina,Jan Schirawski,Artemio Mendoza-Mendoza,Doris Greilinger,Karin Münch,Nicole Rössel,Mario Scherer,Miroslav Vranes,Oliver Ladendorf,Volker Vincon,Uta Fuchs,Björn Sandrock,Shaowu Meng,Eric C.H. Ho,Matt J. Cahill,Kylie J. Boyce,Jana Klose,Steven J. Klosterman,Heine J. Deelstra,Lucila Ortiz-Castellanos,Weixi Li,Patricia Sánchez-Alonso,Peter Schreier,Isolde Häuser-Hahn,Martin Vaupel,Edda Koopmann,Gabi Friedrich,Hartmut Voss,Thomas Schlüter,Jonathan Margolis,Darren Mark Platt,Candace Swimmer,Andreas Gnirke,Feng Chen,Valentina Vysotskaia,Gertrud Mannhaupt,Ulrich Güldener,Martin Münsterkötter,Dirk Haase,Matthias Oesterheld,Hans-Werner Mewes,Evan Mauceli,David DeCaprio,Claire M. Wade,Jonathan Butler,Sarah Young,David B. Jaffe,Sarah E. Calvo,Chad Nusbaum,James E. Galagan,Bruce W. Birren +80 more
TL;DR: The discovery of the secreted protein gene clusters and the functional demonstration of their decisive role in the infection process illuminate previously unknown mechanisms of pathogenicity operating in biotrophic fungi.
Journal ArticleDOI
Phytophthora Genome Sequences Uncover Evolutionary Origins and Mechanisms of Pathogenesis
Brett M. Tyler,Sucheta Tripathy,Xuemin Zhang,Paramvir S. Dehal,Paramvir S. Dehal,Rays H. Y. Jiang,Rays H. Y. Jiang,Andrea Aerts,Andrea Aerts,Felipe D. Arredondo,Laura Baxter,Douda Bensasson,Douda Bensasson,Douda Bensasson,Jim Beynon,Jarrod Chapman,Jarrod Chapman,Jarrod Chapman,C. M. B. Damasceno,Anne E. Dorrance,Daolong Dou,Allan W. Dickerman,Inna Dubchak,Inna Dubchak,Matteo Garbelotto,Mark Gijzen,Stuart G. Gordon,Francine Govers,Niklaus J. Grünwald,Wayne Huang,Wayne Huang,Kelly Ivors,Kelly Ivors,Richard W. Jones,Sophien Kamoun,Konstantinos Krampis,Kurt Lamour,Mi-Kyung Lee,W. Hayes McDonald,MoÌnica Medina,Harold J. G. Meijer,Eric K. Nordberg,Donald J. Maclean,Manuel D. Ospina-Giraldo,Paul Morris,Vipaporn Phuntumart,Nicholas H. Putnam,Nicholas H. Putnam,Sam Rash,Sam Rash,Jocelyn K. C. Rose,Yasuko Sakihama,Asaf Salamov,Asaf Salamov,Alon Savidor,Chantel F. Scheuring,Brian M. Smith,Bruno W. S. Sobral,Astrid Terry,Astrid Terry,Trudy Torto-Alalibo,Joe Win,Zhanyou Xu,Hong-Bin Zhang,Igor V. Grigoriev,Igor V. Grigoriev,Daniel S. Rokhsar,Daniel S. Rokhsar,Jeffrey L. Boore +68 more
TL;DR: Comparison of the two species' genomes reveals a rapid expansion and diversification of many protein families associated with plant infection such as hydrolases, ABC transporters, protein toxins, proteinase inhibitors, and, in particular, a superfamily of 700 proteins with similarity to known oömycete avirulence genes.
Journal ArticleDOI
Proteomic analysis of a eukaryotic cilium
TL;DR: This paper used mass spectrometry to identify proteins in purified flagella from the green alga Chlamydomonas reinhardtii and found that flagellum is rich in motor and signal transduction components, and contains numerous proteins with homologues associated with diseases such as cystic kidney disease, male sterility, and hydrocephalus in humans and model vertebrates.
Related Papers (5)
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.
Brian J. Haas,Sophien Kamoun,Sophien Kamoun,Michael C. Zody,Michael C. Zody,Rays H. Y. Jiang,Rays H. Y. Jiang,Robert E. Handsaker,Liliana M. Cano,Manfred Grabherr,Chinnappa D. Kodira,Chinnappa D. Kodira,Sylvain Raffaele,Trudy Torto-Alalibo,Trudy Torto-Alalibo,Tolga O. Bozkurt,Audrey M. V. Ah-Fong,Lucia Alvarado,Vicky L. Anderson,Miles R. Armstrong,Anna O. Avrova,Laura Baxter,Jim Beynon,Petra C. Boevink,Stephanie R. Bollmann,Jorunn I. B. Bos,Vincent Bulone,Guohong Cai,Cahid Cakir,James C. Carrington,Megan Chawner,Lucio Conti,Stefano Costanzo,Richard Ewan,Noah Fahlgren,Michael A. Fischbach,Johanna Fugelstad,Eleanor M. Gilroy,Sante Gnerre,Pamela J. Green,Laura J. Grenville-Briggs,John Griffith,Niklaus J. Grünwald,Karolyn Horn,Neil R. Horner,Chia-Hui Hu,Edgar Huitema,Dong-Hoon Jeong,Alexandra M. E. Jones,Jonathan D. G. Jones,Richard W. Jones,Elinor K. Karlsson,Sridhara G. Kunjeti,Kurt Lamour,Zhenyu Liu,Li-Jun Ma,Dan MacLean,Marcus C. Chibucos,Hayes McDonald,Jessica McWalters,Harold J. G. Meijer,William Morgan,Paul Morris,Carol A. Munro,Keith O'Neill,Keith O'Neill,Manuel D. Ospina-Giraldo,Andrés Pinzón,Leighton Pritchard,Bernard H Ramsahoye,Qinghu Ren,Silvia Restrepo,Sourav Roy,Ari Sadanandom,Alon Savidor,Sebastian Schornack,David C. Schwartz,Ulrike Schumann,Ben Schwessinger,Lauren Seyer,Ted Sharpe,Cristina Silvar,Jing Song,David J. Studholme,Sean M. Sykes,Marco Thines,Marco Thines,Peter J. I. van de Vondervoort,Vipaporn Phuntumart,Stephan Wawra,R. Weide,Joe Win,Carolyn A. Young,Shiguo Zhou,William E. Fry,Blake C. Meyers,Pieter van West,Jean B. Ristaino,Francine Govers,Paul R. J. Birch,Stephen C. Whisson,Howard S. Judelson,Chad Nusbaum +102 more
Phytophthora Genome Sequences Uncover Evolutionary Origins and Mechanisms of Pathogenesis
Brett M. Tyler,Sucheta Tripathy,Xuemin Zhang,Paramvir S. Dehal,Paramvir S. Dehal,Rays H. Y. Jiang,Rays H. Y. Jiang,Andrea Aerts,Andrea Aerts,Felipe D. Arredondo,Laura Baxter,Douda Bensasson,Douda Bensasson,Douda Bensasson,Jim Beynon,Jarrod Chapman,Jarrod Chapman,Jarrod Chapman,C. M. B. Damasceno,Anne E. Dorrance,Daolong Dou,Allan W. Dickerman,Inna Dubchak,Inna Dubchak,Matteo Garbelotto,Mark Gijzen,Stuart G. Gordon,Francine Govers,Niklaus J. Grünwald,Wayne Huang,Wayne Huang,Kelly Ivors,Kelly Ivors,Richard W. Jones,Sophien Kamoun,Konstantinos Krampis,Kurt Lamour,Mi-Kyung Lee,W. Hayes McDonald,MoÌnica Medina,Harold J. G. Meijer,Eric K. Nordberg,Donald J. Maclean,Manuel D. Ospina-Giraldo,Paul Morris,Vipaporn Phuntumart,Nicholas H. Putnam,Nicholas H. Putnam,Sam Rash,Sam Rash,Jocelyn K. C. Rose,Yasuko Sakihama,Asaf Salamov,Asaf Salamov,Alon Savidor,Chantel F. Scheuring,Brian M. Smith,Bruno W. S. Sobral,Astrid Terry,Astrid Terry,Trudy Torto-Alalibo,Joe Win,Zhanyou Xu,Hong-Bin Zhang,Igor V. Grigoriev,Igor V. Grigoriev,Daniel S. Rokhsar,Daniel S. Rokhsar,Jeffrey L. Boore +68 more
Genome expansion and gene loss in powdery mildew fungi reveal tradeoffs in extreme parasitism
Pietro Spanu,James Abbott,Joelle Amselem,Timothy A. Burgis,Darren M. Soanes,Kurt Stüber,Emiel Ver Loren van Themaat,James K. M. Brown,Sarah Butcher,Sarah J. Gurr,Marc-Henri Lebrun,Christopher J. Ridout,Paul Schulze-Lefert,Nicholas J. Talbot,Nahal Ahmadinejad,Christian Ametz,Geraint Barton,Mariam Benjdia,Przemyslaw Bidzinski,Laurence V. Bindschedler,Maike Both,Marin Talbot Brewer,Lance Cadle-Davidson,Lance Cadle-Davidson,Molly Cadle-Davidson,Jérôme Collemare,Rainer Cramer,Omer Frenkel,Dale Godfrey,James Harriman,Claire Hoede,Brian C. King,Sven Klages,Jochen Kleemann,Daniela Knoll,Prasanna Koti,Jonathan Kreplak,Francisco J. Lopez-Ruiz,Xunli Lu,Takaki Maekawa,Siraprapa Mahanil,Cristina Micali,Michael G. Milgroom,Giovanni Montana,Sandra Noir,Richard J. O'Connell,Simone Oberhaensli,Francis Parlange,Carsten Pedersen,Hadi Quesneville,Richard Reinhardt,Matthias Rott,Soledad Sacristán,Sarah M. Schmidt,Moritz Schön,Pari Skamnioti,Hans Sommer,Amber E. Stephens,Hiroyuki Takahara,Hans Thordal-Christensen,Marielle Vigouroux,Ralf Weßling,Thomas Wicker,Ralph Panstruga +63 more