Q
Quan Chen
Researcher at Nankai University
Publications - 244
Citations - 20608
Quan Chen is an academic researcher from Nankai University. The author has contributed to research in topics: Medicine & Mitochondrion. The author has an hindex of 52, co-authored 154 publications receiving 16697 citations. Previous affiliations of Quan Chen include Chinese Academy of Fishery Sciences & Chinese Academy of Sciences.
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Journal Article
Ionizing radiation-induced, Bax-mediated cell death is dependent on activation of cysteine and serine proteases.
TL;DR: This study found that gamma-radiation-induced apoptosis of leukemia cells was associated with activation of multiple caspases and bax up-regulation, and inhibitors of caspase and serine proteases partially prevented cell death, suggesting a casp enzyme involvement in Bax-mediated cell death.
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Arsenic trioxide (As2O3) induces apoptosis through activation of Bax in hematopoietic cells
Yanhua Zheng,Hirohito Yamaguchi,Changhai Tian,Michael W. Lee,Hong Tang,Hong Gang Wang,Quan Chen +6 more
TL;DR: The data suggest that As2O3 might exert the cell killing in part by inducing Bax activation through a Bcl-2-suppressible pathway in hematopoietic cells that is caspase independent and intracellular ROS regulated.
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Morphine induces Beclin 1- and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus.
Lixia Zhao,Yushan Zhu,Dongmei Wang,Ming Chen,Ping Gao,Weiming Xiao,Guanhua Rao,Xiaohui Wang,Haijing Jin,Lin Xu,Nan Sui,Quan Chen +11 more
TL;DR: It is shown that morphine induces autophagy in Neuroblastoma SH-SY5Y cells and in the rat hippocampus, and pharmacological approach shows that this effect appears to be mediated by PTX-sensitive G protein-coupled receptors signaling cascade.
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Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate.
Kaili Ma,Zhi Zhang,Rui Chang,Hongcheng Cheng,Chenglong Mu,Tian Zhao,Linbo Chen,Chuanmei Zhang,Qian Luo,Jialing Lin,Yushan Zhu,Quan Chen,Quan Chen +12 more
TL;DR: PGAM5, which exists in an equilibrium between dimeric and multimeric states, dephosphorylates BCL-xL to inhibit apoptosis or FUNDC1 to activate mitofission and mitophagy in response to distinct stresses.
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A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity.
Yanjun Li,Yanhong Xue,Xiaojun Xu,Guopeng Wang,Yiqun Liu,Hao Wu,Wenhui Li,Yueying Wang,Ziheng Chen,Weilin Zhang,Yushan Zhu,Wei Ji,Tao Xu,Tao Xu,Lei Liu,Quan Chen,Quan Chen +16 more
TL;DR: It is suggested that human mitochondria organize cellular proteostatic response at the risk of their own malfunction and cell lethality.