Q
Quan Chen
Researcher at Nankai University
Publications - 244
Citations - 20608
Quan Chen is an academic researcher from Nankai University. The author has contributed to research in topics: Medicine & Mitochondrion. The author has an hindex of 52, co-authored 154 publications receiving 16697 citations. Previous affiliations of Quan Chen include Chinese Academy of Fishery Sciences & Chinese Academy of Sciences.
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Journal ArticleDOI
TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel.
Qiao Chu Wang,Qiaoxia Zheng,Haiyan Tan,Bing Zhang,Xiaoling Li,Yuxiu Yang,Jie Yu,Yang Liu,Hao Chai,Xi Wang,Zhongshuai Sun,Jiu Qiang Wang,Shu Zhu,Fengli Wang,Maojun Yang,Caixia Guo,Heng Wang,Qingyin Zheng,Yang Li,Quan Chen,Aimin Zhou,Tie-Shan Tang +21 more
TL;DR: It is shown that TMCO1 is an ER transmembrane protein that actively prevents Ca(2+) stores from overfilling, acting as what the authors term a "Ca(2-) load-activated Ca( 2+) channel" or "CLAC" channel.
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Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy
Jie Li,Wei Qi,Guo Chen,Du Feng,Jinhua Liu,Biao Ma,Changqian Zhou,Chenglong Mu,Weilin Zhang,Quan Chen,Yushan Zhu +10 more
TL;DR: MUL1, a mitochondria-localized E3 ligase, regulates selenite-induced mitophagy in an ATG5 and ULK1-dependent manner and is demonstrated to provide a new mechanism for the beneficial effects of selenium as a chemopreventive agent.
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Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.
Hao Wu,You Wang,Wenhui Li,Hui Chen,Lei Du,Dong Liu,Xiaohui Wang,Tao Xu,Lei Liu,Quan Chen,Quan Chen +10 more
TL;DR: The results demonstrate that dysregulated mitochondrial QC due to defective mitophagy receptor FUNDC1 links with metabolic disorders via MAPK signaling and inflammatory responses.
Journal ArticleDOI
Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer
Guanhua Rao,Hongyi Wang,Baowei Li,Li Huang,Danfeng Xue,Xiaohui Wang,Haijing Jin,Jun Wang,Yushan Zhu,Youyong Lu,Lei Du,Quan Chen +11 more
TL;DR: It is found that macrophages, when coinjected or cocultured with CD44-positive colorectal cancer cells, were able to produce higher levels of OPN, which in turn facilitated the tumorigenicity and clonogenicity of the colorec cancer cells.
Journal ArticleDOI
Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis.
Chunlai Nie,Changhai Tian,Lixia Zhao,Patrice X. Petit,Maryam Mehrpour,Maryam Mehrpour,Quan Chen +6 more
TL;DR: It is shown that H2O2 induces Bax conformational change, mitochondrial translocation, and subsequent oligomerization at mitochondria, and a critical role of cysteine 62 is identified in oxidative stress-induced Bax activation and subsequent apoptosis.