Q
Quan Chen
Researcher at Nankai University
Publications - 244
Citations - 20608
Quan Chen is an academic researcher from Nankai University. The author has contributed to research in topics: Medicine & Mitochondrion. The author has an hindex of 52, co-authored 154 publications receiving 16697 citations. Previous affiliations of Quan Chen include Chinese Academy of Fishery Sciences & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
PINK1‐mediated mitophagy maintains pluripotency through optineurin
Chaoqun Wang,Chaoqun Wang,Kun Liu,Jiani Cao,Liang Wang,Qian Zhao,Zheng Li,Honghai Zhang,Quan Chen,Tongbiao Zhao,Tongbiao Zhao +10 more
TL;DR: In this article, the molecular mechanisms that regulate mitochondrial homeostasis for pluripotency regulation in mouse ESCs were dissected, and the mitophagy receptor OPTN guards ESC mitochondria by scavenging damaged mitochondria through TBK1-activated OPTN binding of PINK1-phosphorylated Ubiquitin.
Patent
Human colorectal adenocarcinoma tumor cell line as well as preparation method and application thereof
TL;DR: In this article, a human colorectal adenocarcinoma tumor cell line as well as a preparation method and an application of the cell line is provided. But the method is not suitable for the treatment of cancer.
Journal ArticleDOI
Development and validation of a transcriptomics-based gene signature to predict distant metastasis and guide induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma.
Sai-Lan Liu,Xue Song Sun,Quan Chen,Zexian Liu,Li-juan Bian,Li Yuan,Bei Bei Xiao,Zi-Jian Lu,Xiao-Yun Li,Jin Jie Yan,Shumei Yan,Jian-Ming Li,Jin Xin Bei,Hai Qiang Mai,Lin Quan Tang +14 more
TL;DR: In this article , a transcriptomics-based gene signature was established to assess the risk of distant metastasis and guide IC in locoregionally advanced nasopharyngeal carcinoma (NPC).
Journal ArticleDOI
BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy
Kun Liu,Qian Zhao,Hongyan Sun,Lei Liu,Chaoqun Wang,Zheng Li,Youqing Xu,Liang Wang,Lin Zhang,Honghai Zhang,Quan Chen,Tong-Wei Zhao +11 more
TL;DR: In this article , the mitophagy receptor BNIP3 was found to play pivotal roles in both the acquisition and maintenance of pluripotency, and the molecular mechanisms that link autophagy-mediated mitochondrial homeostasis to pluripOTency regulation are unclear.