Q
Quan Chen
Researcher at Nankai University
Publications - 244
Citations - 20608
Quan Chen is an academic researcher from Nankai University. The author has contributed to research in topics: Medicine & Mitochondrion. The author has an hindex of 52, co-authored 154 publications receiving 16697 citations. Previous affiliations of Quan Chen include Chinese Academy of Fishery Sciences & Chinese Academy of Sciences.
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MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy.
TL;DR: A striking piece of evidence is uncovered to demonstrate that the mitophagy receptor FUNDC1 is a substrate of MARCH5, a mitochondrially localized E3 ubiquitin ligase that circumvents injudicious removal of cellular mitochondria.
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Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes
Xudong Liao,Jun-Ming Liu,Lei Du,Ai-Hui Tang,Yingli Shang,Shi-Qiang Wang,Lan-Ying Chen,Quan Chen +7 more
TL;DR: It is shown that endogenous NO signaling plays a critical role in mechanical stretch‐induced cardiomyocyte apoptosis and mechanical signals initiate Ca2+‐dependent NO synthesis, which is further amplified by activation of NO‐induced iNOS expression, to regulateCardiomyocytes apoptosis.
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The role of Akt on Arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation
TL;DR: The results suggested that Akt/PKB may play a role in suppression of apoptosis and negatively regulate preadipocyte differentiation, and appears to block the arsenic trioxide suppression of differentiation.
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A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells
Li Huang,Junjie Han,Danya Ben-Hail,Luwei He,Baowei Li,Ziheng Chen,Yueying Wang,Yan-lei Yang,Lei Liu,Yushan Zhu,Varda Shoshan-Barmatz,Hongwei Liu,Quan Chen +12 more
TL;DR: A new compound promoting VDAC1-dependent apoptosis is identified as a potential therapeutic option for cancerous cells lacking or presenting inactivated Bax/Bak.
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Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs
Guanhua Rao,Hong-min Liu,Baowei Li,Jia-jie Hao,Yan-lei Yang,Ming-rong Wang,Xiaohui Wang,Jun Wang,Haijing Jin,Lei Du,Quan Chen +10 more
TL;DR: A CD44+ colorectal cancer stem cell line P6C is established with particular emphasis on its self-renewal capacity, enhanced tumor initiation and drug resistance, which will benefit the mechanistic studies on cancer stem cells and the development of drugs that specifically target the cancer stem Cells.