Q
Quan Chen
Researcher at Nankai University
Publications - 244
Citations - 20608
Quan Chen is an academic researcher from Nankai University. The author has contributed to research in topics: Medicine & Mitochondrion. The author has an hindex of 52, co-authored 154 publications receiving 16697 citations. Previous affiliations of Quan Chen include Chinese Academy of Fishery Sciences & Chinese Academy of Sciences.
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Journal ArticleDOI
Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2
Xiaobo Lei,Yingyu Chen,Guanhua Du,Wenyu Yu,Xiaohui Wang,Hong Qu,Bin Xia,Hong-Ping He,Jian-Hua Mao,Wei-Xing Zong,Xudong Liao,Maryam Mehrpour,Xiao-Jiang Hao,Quan Chen +13 more
TL;DR: It is concluded that gossypol converts the antiapoptotic molecule Bcl‐2 into a proapoptosis molecule that can mediate the release of cyto c and induce apoptosis.
Journal ArticleDOI
A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia
Qun-Ye Zhang,Jian-Hua Mao,Ping Liu,Qiu-Hua Huang,Jing Lu,Yin-Yin Xie,Lin Weng,Yan Zhang,Quan Chen,Sai Juan Chen,Zhu Chen +10 more
TL;DR: Combination of the 2 agents synergistically arrests the cell cycle, decreases activity of BCR/ABL, and leads to activation of intrinsic and extrinsic apoptosis pathways through complex modifications to both transcription and protein levels suggest potential clinical benefits of IM/AS combination therapy for human CML.
Journal ArticleDOI
The Bcl-2 Homology Domain 3 Mimetic Gossypol Induces Both Beclin 1-dependent and Beclin 1-independent Cytoprotective Autophagy in Cancer Cells
Ping Gao,Chantal Bauvy,Sylvie Souquere,Giovanni Tonelli,Lei Liu,Yushan Zhu,Zhenzhen Qiao,Daniela Bakula,Tassula Proikas-Cezanne,Gérard Pierron,Patrice Codogno,Quan Chen,Quan Chen,Maryam Mehrpour +13 more
TL;DR: Evidence that gossypol induces autophagy followed by apoptotic cell death in both the MCF-7 human breast adenocarcinoma and HeLa cell lines is provided and this support the notion that gOSSypol-inducedAutophagy is cytoprotective and not part of the cell death process induced by this compound.
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FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice.
Wenhui Li,Yanjun Li,Sami Siraj,Sami Siraj,Haojie Jin,Yuyuan Fan,Xin-Rong Yang,Xiao-Wu Huang,Xiaohui Wang,Jun Wang,Lei Liu,Lei Du,Quan Chen,Quan Chen +13 more
TL;DR: A mechanistic link between mitophagic modulation of inflammatory response and tumorigenesis is described, which implies that FUNDC1‐mediated mitophagy and its related inflammatory response may represent a therapeutic target for liver cancer.
Journal ArticleDOI
Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration
Hongyu Zhao,Yan G. Zhao,Xingwei Wang,Lanjun Xu,Lin Miao,Du Feng,Quan Chen,Attila L. Kovács,Dongsheng Fan,Hong Zhang +9 more
TL;DR: Cortical layer 5 pyramidal neurons and spinal cord motor neurons are selectively vulnerable to degeneration after loss of the autophagy gene Epg5.