Q
Quan Chen
Researcher at Nankai University
Publications - 244
Citations - 20608
Quan Chen is an academic researcher from Nankai University. The author has contributed to research in topics: Medicine & Mitochondrion. The author has an hindex of 52, co-authored 154 publications receiving 16697 citations. Previous affiliations of Quan Chen include Chinese Academy of Fishery Sciences & Chinese Academy of Sciences.
Papers
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Journal ArticleDOI
Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy.
Hao Wu,Hao Wu,Huifang Wei,Di Zhang,Sheikh Arslan Sehgal,Dejiu Zhang,Xiaohui Wang,Yan Qin,Lei Liu,Quan Chen,Quan Chen +10 more
TL;DR: It is reported that mitochondrial ISCs biogenesis is coupled with receptor-mediated mitophagy in mammalian cells, and it is concluded that ISCs serve as physiological signals forMitophagy activation, thus coupling mitophileagy with iron metabolism.
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Endophilin B2 promotes inner mitochondrial membrane degradation by forming heterodimers with Endophilin B1 during mitophagy.
Yi-Han Wang,Jiu-Qiang Wang,Qiao-Chu Wang,Yun Wang,Caixia Guo,Quan Chen,Tuanyao Chai,Tie-Shan Tang +7 more
TL;DR: It is reported that EB2 plays an indispensable role in mitochondria sequestration and inner mitochondrial membrane (IMM) protein degradation during mitophagy and it is proposed that EB1/EB2 heterodimers may serve as linkers between damaged mitochondria and phagophores duringMitophagy.
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Phenylarsine Oxide Induces Apoptosis in Bax- and Bak-Deficient Cells through Upregulation of Bim
TL;DR: PAO induced apoptosis in chemotherapy-resistant cancer cells, which suggests that PAO has the potential to serve as a chemotherapeutic agent for Bax- and Bak-deficient cancers.
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A zinc transporter, transmembrane protein 163, is critical for the biogenesis of platelet dense granules.
Yefeng Yuan,Yefeng Yuan,Teng Liu,Teng Liu,Xiahe Huang,Yuanying Chen,Weilin Zhang,Ting Li,Lin Yang,Quan Chen,Quan Chen,Yingchun Wang,Aihua Wei,Li Wei,Li Wei +14 more
TL;DR: In this article, the transmembrane protein 163 (TMEM163) was found to be critical for platelet dense granules (DGs) and melanosomes.
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Remarkably reduced expression of FoxO3a in metaplastic colorectum, primary colorectal cancer and liver metastasis.
Leya He,Xin Wei,Lei Du,Lu Liu,Feng Xu,Jiang Min,Chuan Li,Deding Tao,Quan Chen,Junbo Hu,Jianping Gong +10 more
TL;DR: It is concluded that the downregulation of FoxO3a may greatly contribute to tumor development, and thus FoxO 3a may represent a novel therapeutic target in colorectal cancer.