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Open AccessJournal ArticleDOI

Production of Reactive Oxygen Species by Mitochondria: CENTRAL ROLE OF COMPLEX III *

Qun Chen, +6 more
- 19 Sep 2003 - 
- Vol. 278, Iss: 38, pp 36027-36031
TLDR
In this paper, the authors measured reactive oxygen species (ROS) in the mitochondria of Sprague-Dawley rat heart and corresponding submitochondrial particles using the amplex red assay.
About: 
This article is published in Journal of Biological Chemistry.The article was published on 2003-09-19 and is currently open access. It has received 1406 citations till now. The article focuses on the topics: Submitochondrial particle & Coenzyme Q – cytochrome c reductase.

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Citations
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Journal ArticleDOI

Mitochondria, Oxidants, and Aging

Robert S. Balaban, +2 more
- 25 Feb 2005 - 
TL;DR: The evidence is reviewed that both supports and conflicts with the free radical theory of aging and the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging is examined.
Journal ArticleDOI

ROS and ROS-Mediated Cellular Signaling

Jixiang Zhang, +6 more
- 22 Feb 2016 - 
TL;DR: This review paper focuses on the pattern of the generation and homeostasis of intracellular ROS, the mechanisms and targets of ROS impacting on cell-signaling proteins, ion channels and transporters, and modifying protein kinase and Ubiquitination/Proteasome System.
Journal ArticleDOI

The sites and topology of mitochondrial superoxide production

Martin D. Brand
- 01 Aug 2010 - 
TL;DR: The relative contribution of each site to mitochondrial reactive oxygen species generation in the absence of electron transport inhibitors is unknown in isolated mitochondria, in cells or in vivo, and may vary considerably with species, tissue, substrate, energy demand and oxygen tension.
Journal ArticleDOI

Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

Fernanda G. De Felice, +7 more
- 13 Apr 2007 - 
TL;DR: This response provides a pathologically specific mechanism for the therapeutic action of memantine, indicates a role for ROS dysregulation in ADDL-induced cognitive impairment, and supports the unifying hypothesis that ADDLs play a central role in AD pathogenesis.
Journal ArticleDOI

Oxidative stress in the placenta

Leslie Myatt, +1 more
- 10 Jul 2004 - 
TL;DR: In late gestation increased oxidative stress is seen in pregnancies complicated by diabetes, IUGR, and preeclampsia in association with increased trophoblast apoptosis and deportation and altered placental vascular reactivity.
References
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Journal ArticleDOI

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.

J F Turrens, +1 more
- 01 Nov 1980 - 
TL;DR: An O2- -dependent autocatalytic process that requires NADH, submitochondrial particles and adrenaline is described.
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Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain

Julie St-Pierre, +3 more
- 22 Nov 2002 - 
TL;DR: The results do not support the idea that mitochondria produce considerable amounts of reactive oxygen species under physiological conditions and the proportion of electron flow giving rise to hydrogen peroxide with palmitoyl carnitine as substrate is more than an order of magnitude lower than commonly cited values.
Journal ArticleDOI

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria.

Julio F. Turrens, +3 more
- 01 Mar 1985 - 
TL;DR: Experiments with succinate as electron donor in the presence of antimycin A in intact rat heart mitochondria showed that myxothiazol, which inhibits reduction of the Rieske iron-sulfur center, prevented formation of hydrogen peroxide, determined spectrophotometrically as the H2O2-peroxidase complex.
Journal ArticleDOI

Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex.

So Iwata, +8 more
- 03 Jul 1998 - 
TL;DR: In this article, crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme, and the "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms.
Journal ArticleDOI

Oxygen activation and the conservation of energy in cell respiration.

Gerald T. Babcock, +1 more
- 26 Mar 1992 - 
TL;DR: The molecular mechanism of 02 reduction and its linkage to H+ translocation are now emerging and the bimetallic haem iron–copper reaction centre in this family of enzymes is the critical structure for catalysis of both these processes.