R
Raghu Kalluri
Researcher at University of Texas MD Anderson Cancer Center
Publications - 325
Citations - 89851
Raghu Kalluri is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Angiogenesis. The author has an hindex of 115, co-authored 306 publications receiving 71127 citations. Previous affiliations of Raghu Kalluri include Beth Israel Deaconess Medical Center & Baylor College of Medicine.
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Journal ArticleDOI
Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease.
Hikaru Sugimoto,Thomas M. Mundel,Malin Sund,Liang Xie,Dominic Cosgrove,Raghu Kalluri,Raghu Kalluri +6 more
TL;DR: It is demonstrated that BM-derived stem cells can offer a viable strategy for repairing basement membrane defects and conferring therapeutic benefit for patients with Alport syndrome.
Journal ArticleDOI
Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors
Thomas De Raedt,Zandra E. Walton,Jessica L. Yecies,Danan Li,Yimei Chen,Clare F. Malone,Clare F. Malone,Ophélia Maertens,Ophélia Maertens,Seung Min Jeong,Roderick T. Bronson,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri,Emmanuel Normant,Marcia C. Haigis,Brendan D. Manning,Kwok-Kin Wong,Kwok-Kin Wong,Kay F. Macleod,Karen Cichowski,Karen Cichowski +22 more
TL;DR: This work shows that agents that enhance proteotoxic stress, including the HSP90 inhibitor IPI-504, induce tumor regression in aggressive mouse models, but only when combined with rapamycin, and reveals a therapeutic paradigm that can be expanded to develop additional combinations.
Journal ArticleDOI
Contribution of bone microenvironment to leukemogenesis and leukemia progression.
TL;DR: Leukemia-associated bone microenvironment markers could be used as prognostic or predictive indicators of disease progression and/or treatment outcome and would likely provide a better understanding of the treatment resistance associated with leukemia therapy and design of new treatments.
Journal ArticleDOI
Origins of Cardiac Fibroblasts
TL;DR: Evidence is evolving that cardiac fibroblasts are a heterogeneous population and likely derive from various distinct tissue niches in health and disease and how to use this knowledge to develop novel therapies for cardiac fibrosis is reviewed.
Journal ArticleDOI
Mice deficient in α-actinin-4 have severe glomerular disease
Claudine H. Kos,Tu Cam Le,Sumita Sinha,Joel M. Henderson,Sung Han Kim,Hikaru Sugimoto,Raghu Kalluri,Robert E. Gerszten,Martin R. Pollak +8 more
TL;DR: It is concluded that α-actinin-4 is required for normal glomerular function and the nonsarcomeric forms of α-Actininin (α-act inin-1 and α- actin in-4) are not functionally redundant, and these genetic studies demonstrate that the nonsArcomeric α- Actn4 is involved in the regulation of cell movement.