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Enrique Vidal
Researcher at Pompeu Fabra University
Publications - 50
Citations - 2923
Enrique Vidal is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 31, co-authored 48 publications receiving 2452 citations. Previous affiliations of Enrique Vidal include Carlos III Health Institute.
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Journal ArticleDOI
Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming
Ralph Stadhouders,Ralph Stadhouders,Enrique Vidal,François Serra,Bruno Di Stefano,Bruno Di Stefano,François Le Dily,Javier Quilez,Antonio Gomez,Samuel Collombet,Clara Berenguer,Yasmina Cuartero,Jochen Hecht,Guillaume J. Filion,Miguel Beato,Marc A. Marti-Renom,Thomas Graf +16 more
TL;DR: It is concluded that 3D genome reorganization generally precedes gene expression changes and that removal of locus-specific topological barriers explains why pluripotency genes are activated sequentially during reprogramming.
Journal ArticleDOI
Validation of the geographic position of EPER-Spain industries
Javier García-Pérez,Elena Boldo,Rebeca Ramis,Enrique Vidal,Nuria Aragonés,Beatriz Pérez-Gómez,Marina Pollán,Gonzalo López-Abente +7 more
TL;DR: Knowing the exact location of pollutant foci is vital to obtain reliable and valid conclusions in any study where distance to the focus is a decisive factor, as in the case of the consequences of industrial pollution on the health of neighbouring populations.
Journal ArticleDOI
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer.
Holger Heyn,Enrique Vidal,Humberto J. Ferreira,Miguel Vizoso,Sergi Sayols,Antonio Gomez,Sebastian Moran,Raquel Boque-Sastre,Sonia Guil,Anna Martínez-Cardús,Charles Y. Lin,Charles Y. Lin,Romina Royo,Jose V. Sanchez-Mut,Ramon Martinez,Marta Gut,David Torrents,David Torrents,Modesto Orozco,Modesto Orozco,Ivo Gut,Richard A. Young,Manel Esteller,Manel Esteller +23 more
TL;DR: In this paper, the authors used bisulfite sequencing to examine uncharted regions of the epigenome and identify a type of far-reaching DNA methylation alteration in cancer cells of the distal regulatory sequences described as super-enhancers.
Journal ArticleDOI
Putative cis -regulatory drivers in colorectal cancer
Halit Ongen,Halit Ongen,Claus L. Andersen,Jesper B. Bramsen,Bodil Øster,Mads Rasmussen,Pedro G. Ferreira,Pedro G. Ferreira,Juan Sandoval,Enrique Vidal,Nicola Whiffin,Alexandra Planchon,Alexandra Planchon,Ismael Padioleau,Ismael Padioleau,Deborah Bielser,Deborah Bielser,Luciana Romano,Luciana Romano,Ian Tomlinson,Richard S. Houlston,Manel Esteller,Manel Esteller,Torben F. Ørntoft,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis +25 more
TL;DR: An RNA-sequencing experiment of matched tumour and normal colon mucosa samples from Danish CRC patients reveals a substantial number of putative somatic and germline cis-regulatory cancer changes that may have a role in tumorigenesis.
Journal ArticleDOI
Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns.
Jose V. Sanchez-Mut,Holger Heyn,Enrique Vidal,Sebastian Moran,Sergi Sayols,Raul Delgado-Morales,Matthew D. Schultz,Matthew D. Schultz,Belén Ansoleaga,Paula Garcia-Esparcia,Meritxell Pons-Espinal,M M de Lagran,Joaquín Dopazo,Alberto Rábano,Jesús Avila,Mara Dierssen,Ira T. Lott,Isidre Ferrer,Joseph R. Ecker,Manel Esteller,Manel Esteller +20 more
TL;DR: The findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities, and aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies.