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Robert A.J. Signer
Researcher at University of California, San Diego
Publications - 36
Citations - 2487
Robert A.J. Signer is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 18, co-authored 29 publications receiving 1986 citations. Previous affiliations of Robert A.J. Signer include University of California, Los Angeles & University of Texas Southwestern Medical Center.
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Haematopoietic stem cells require a highly regulated protein synthesis rate
TL;DR: It is found that the amount of protein synthesized per hour in HSCs in vivo was lower than in most other haematopoietic cells, even if it was controlled for differences in cell cycle status or forced H SCs to undergo self-renewing divisions.
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The ageing immune system: is it ever too old to become young again?
TL;DR: The promise of various approaches to rejuvenate the function of the immune system in the rapidly growing ageing population is reviewed.
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Mechanisms that Regulate Stem Cell Aging and Life Span
TL;DR: It remains unknown whether declines in stem cell function during aging influence organismal longevity, however, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.
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Cellular differences in protein synthesis regulate tissue homeostasis
TL;DR: Although sometimes considered a "house-keeping" function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner.
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Lens regeneration using endogenous stem cells with gain of visual function
Haotian Lin,Hong Ouyang,Jie Zhu,Shan Huang,Zhenzhen Liu,Shuyi Chen,Guiqun Cao,Gen Li,Robert A.J. Signer,Yanxin Xu,Christopher Chung,Ying Zhang,Danni Lin,Sherrina Patel,Frances Wu,Huimin Cai,Jiayi Hou,Cindy Wen,Maryam Jafari,Xialin Liu,Lixia Luo,Jin Zhu,Austin Qiu,Rui Hou,Baoxin Chen,Jiangna Chen,David B. Granet,Christopher W.D. Heichel,Fu Shang,Xuri Li,Michal Krawczyk,Dorota Skowronska-Krawczyk,Yujuan Wang,William Shi,Daniel Chen,Zheng Zhong,Zheng Zhong,Sheng Zhong,Liangfang Zhang,Shaochen Chen,Sean J. Morrison,Richard L. Maas,Kang Zhang,Yizhi Liu +43 more
TL;DR: This work designs a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts, and provides a new paradigm for tissue regeneration using endogenous stem cells.