Jin Zhu

TL;DR: Establishment of an in vitro feeder-cell-free LSC expansion and three-dimensional corneal differentiation protocol in which the transcription factors p63 and PAX6 act together to specify LSCs is found, suggesting a central role of the WNT7A–PAX6 axis in corNEal epithelial cell fate determination, and point to a new strategy for treating corneAL surface diseases.

TL;DR: This work designs a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts, and provides a new paradigm for tissue regeneration using endogenous stem cells.

TL;DR: It is demonstrated that CFH binds to oxPLs and that oxPL stimulation increases expression of genes involved in macrophage infiltration, inflammation, and neovascularization in the eye.

TL;DR: It is demonstrated that the genetic effect of the SIX6 risk variant is enhanced by another major POAG risk gene, p16INK4a, which leads to RGC senescence in adult human retinas, providing a unified theory of glaucoma pathogenesis.

TL;DR: Data from this study show that TCF7L2-rs7903146 is associated with PDR in Caucasian T2DM and suggest thatTCF 7L2 promotes pathological retinal neovascularization via ER stress–dependent upregulation of VEGFA.