Guiqun Cao

TL;DR: In this paper, the authors identify two distinct homozygous LSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts.

TL;DR: Establishment of an in vitro feeder-cell-free LSC expansion and three-dimensional corneal differentiation protocol in which the transcription factors p63 and PAX6 act together to specify LSCs is found, suggesting a central role of the WNT7A–PAX6 axis in corNEal epithelial cell fate determination, and point to a new strategy for treating corneAL surface diseases.

TL;DR: This work designs a surgical method of cataract removal that preserves endogenous LECs and achieves functional lens regeneration in rabbits and macaques, as well as in human infants with cataracts, and provides a new paradigm for tissue regeneration using endogenous stem cells.

TL;DR: It is demonstrated that the genetic effect of the SIX6 risk variant is enhanced by another major POAG risk gene, p16INK4a, which leads to RGC senescence in adult human retinas, providing a unified theory of glaucoma pathogenesis.

TL;DR: Loss of PAX6 converts LSCs to epidermal stem cells, as demonstrated by a switch in the keratin gene expression profile and by the appearance of congenital dermoid tissue.