Yizhi Liu

TL;DR: The prevalence of reduced vision because of myopia is high in school-age children living in metropolitan Guangzhou, representing an important public health problem.

TL;DR: In this paper, the authors identify two distinct homozygous LSS missense mutations (W581R and G588S) in two families with extensive congenital cataracts.

TL;DR: The downstream effects of GSH depletion on stress-induced premature senescence (SIPS) and cell death in human RPE cells are examined and it is found that autophagy is activated in the process of ferroptosis and reduces SIPS, suggesting an essential role of autophagic in ferroPTosis and SIPS.

TL;DR: It is shown that an AI agent using deep learning, and involving convolutional neural networks for diagnostics, risk stratification and treatment suggestions, accurately diagnoses and provides treatment decisions for congenital cataracts in an in silico test, a website-based study, in a ‘finding a needle in a haystack’ test and in a multihospital clinical trial.

TL;DR: Establishment of an in vitro feeder-cell-free LSC expansion and three-dimensional corneal differentiation protocol in which the transcription factors p63 and PAX6 act together to specify LSCs is found, suggesting a central role of the WNT7A–PAX6 axis in corNEal epithelial cell fate determination, and point to a new strategy for treating corneAL surface diseases.