R
Robert P. Chase
Researcher at Brigham and Women's Hospital
Publications - 46
Citations - 644
Robert P. Chase is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 30 publications receiving 422 citations. Previous affiliations of Robert P. Chase include Harvard University.
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Journal ArticleDOI
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Brian D. Hobbs,Kim de Jong,Maxime Lamontagne,Yohan Bossé,Nick Shrine,María Soler Artigas,Louise V. Wain,Ian P. Hall,Victoria E. Jackson,Annah B. Wyss,Stephanie J. London,Kari E. North,Nora Franceschini,David P. Strachan,Terri H. Beaty,John E. Hokanson,James D. Crapo,Peter J. Castaldi,Robert P. Chase,Traci M. Bartz,Susan R. Heckbert,Susan R. Heckbert,Bruce M. Psaty,Bruce M. Psaty,Sina A. Gharib,Pieter Zanen,Jan Willem J. Lammers,Matthijs Oudkerk,Harry J.M. Groen,Nicholas Locantore,Ruth Tal-Singer,Stephen I. Rennard,Stephen I. Rennard,Jørgen Vestbo,Wim Timens,Peter D. Paré,Jeanne C. Latourelle,Josée Dupuis,Josée Dupuis,George T. O'Connor,George T. O'Connor,Jemma B. Wilk,Woo Jin Kim,Mi Kyeong Lee,Yeon-Mok Oh,Judith M. Vonk,Harry J. de Koning,Shuguang Leng,Steven A. Belinsky,Yohannes Tesfaigzi,Ani Manichaikul,Xin-Qun Wang,Stephen S. Rich,R. Graham Barr,David Sparrow,Augusto A. Litonjua,Per Bakke,Amund Gulsvik,Lies Lahousse,Lies Lahousse,Guy Brusselle,Guy Brusselle,Bruno H. Stricker,André G. Uitterlinden,Elizabeth J. Ampleford,Eugene R. Bleecker,Prescott G. Woodruff,Deborah A. Meyers,Dandi Qiao,David A. Lomas,Jae-Joon Yim,Deog Kyeom Kim,Iwona Hawryłkiewicz,Pawel Sliwinski,Megan Hardin,Megan Hardin,Tasha E. Fingerlin,David A. Schwartz,Dirkje S. Postma,William MacNee,Martin D. Tobin,Martin D. Tobin,Edwin K. Silverman,H. Marike Boezen,Michael H. Cho +84 more
TL;DR: In the combined meta-analysis, 22 loci associated at genome-wide significance are identified, including 13 new associations with COPD, including 12 associated with lung function in general population samples, while 4 are new.
Journal ArticleDOI
RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking.
Margaret M. Parker,Margaret M. Parker,Robert P. Chase,Andrew Lamb,Alejandro Reyes,Aabida Saferali,Aabida Saferali,Jeong H. Yun,Blanca E. Himes,Edwin K. Silverman,Edwin K. Silverman,Craig P. Hersh,Craig P. Hersh,Peter J. Castaldi,Peter J. Castaldi +14 more
TL;DR: Transcriptomic changes at the gene and exon levels from whole blood can refine the understanding of the molecular mechanisms underlying the response to smoking.
Journal ArticleDOI
CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies
Michael J. McGeachie,Ann Chen Wu,Ann Chen Wu,Sze Man Tse,George L. Clemmer,Joanne E. Sordillo,Blanca E. Himes,Jessica Lasky-Su,Robert P. Chase,Fernando D. Martinez,Peter Weeke,Peter Weeke,Christian M. Shaffer,Hua Xu,Josh C. Denny,Dan M. Roden,Reynold A. Panettieri,Benjamin A. Raby,Scott T. Weiss,Kelan G. Tantisira +19 more
TL;DR: In this article, the authors performed a genome-wide association study meta-analysis of acute asthma exacerbation in two pediatric clinical trials: the Childhood Asthma Management Program (n = 581) and the Childhood ASThma Research and Education (n= 205) network.
Journal ArticleDOI
Circulating MicroRNAs and Treatment Response in Childhood Asthma
Jiang Li,Ronald Allan M Panganiban,Alvin T. Kho,Michael J. McGeachie,Leanna Farnam,Robert P. Chase,Scott T. Weiss,Quan Lu,Kelan G. Tantisira +8 more
TL;DR: Two functional circulating miRNAs were predictive of asthma ICS treatment response over time, with the area under receiver operating characteristic curve (AUROC) of 0.86.
Journal ArticleDOI
RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD
Jarrett D. Morrow,Robert P. Chase,Margaret M. Parker,Kimberly Glass,Minseok Seo,Miguel Divo,Caroline A. Owen,Peter J. Castaldi,Dawn L. DeMeo,Edwin K. Silverman,Craig P. Hersh +10 more
TL;DR: The known smoking-related genes CYP1B1 and AHRR were among the top differential expression results for smoking status in the large-airway epithelium data.