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Robert V. Farese
Researcher at Harvard University
Publications - 484
Citations - 54181
Robert V. Farese is an academic researcher from Harvard University. The author has contributed to research in topics: Insulin & Protein kinase C. The author has an hindex of 115, co-authored 473 publications receiving 48754 citations. Previous affiliations of Robert V. Farese include University of South Florida & University at Buffalo.
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Journal ArticleDOI
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Laura L. Listenberger,Xianlin Han,Sarah Lewis,Sylvaine Cases,Robert V. Farese,Daniel S. Ory,Jean E. Schaffer +6 more
TL;DR: This work demonstrates in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metabolic fates, and supports a model of cellular lipid metabolism in which unsaturated fatty acids serve a protective function against lipotoxicity though promotion of triglyceride accumulation.
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Cellular fatty acid metabolism and cancer
TL;DR: Evidence that limiting fatty acid availability can control cancer cell proliferation is summarized, and a view of cancer cell metabolism from a lipid perspective is provided.
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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Matthew D. Hirschey,Tadahiro Shimazu,Tadahiro Shimazu,Eric S. Goetzman,Enxuan Jing,Bjoern Schwer,Bjoern Schwer,Bjoern Schwer,David B. Lombard,Carrie A. Grueter,Charles A. Harris,Sudha B. Biddinger,Olga Ilkayeva,Robert Stevens,Yu Li,Asish K. Saha,Neil B. Ruderman,James R. Bain,Christopher B. Newgard,Robert V. Farese,Frederick W. Alt,C. Ronald Kahn,Eric Verdin,Eric Verdin +23 more
TL;DR: It is demonstrated that SIRT3 modulates mitochondrial intermediary metabolism and fatty-acid use during fasting and acetylation is identified as a novel regulatory mechanism for mitochondrial fatty- acid oxidation.
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Lipid Droplets and Cellular Lipid Metabolism
TL;DR: The current knowledge of LD cell biology and its translation to physiology is reviewed, finding that many aspects of LD biology are unknown.
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Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Tadahiro Shimazu,Matthew D. Hirschey,John C. Newman,Wenjuan He,Kotaro Shirakawa,Natacha Le Moan,Carrie A. Grueter,Hyung W. Lim,Laura Saunders,Robert Stevens,Christopher B. Newgard,Robert V. Farese,Rafael de Cabo,Scott M. Ulrich,Katerina Akassoglou,Eric Verdin +15 more
TL;DR: It is reported that the ketone body d-β-hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I histone deacetylases (HDACs), and treatment of mice with βOHB conferred substantial protection against oxidative stress.