R
Rocco Latorre
Researcher at New York University
Publications - 43
Citations - 1437
Rocco Latorre is an academic researcher from New York University. The author has contributed to research in topics: Endosome & Enteroendocrine cell. The author has an hindex of 15, co-authored 37 publications receiving 970 citations. Previous affiliations of Rocco Latorre include University of Oklahoma & Columbia University Medical Center.
Papers
More filters
Journal ArticleDOI
Enteroendocrine cells: a review of their role in brain–gut communication
TL;DR: Recent studies have shed light on EEC sensory transmission by showing direct connections between EECs and the nervous system via axon‐like processes that form a well‐defined neuroepithelial circuits through which E ECs can directly communicate with the neurons innervating the GI tract to initiate appropriate functional responses.
Journal ArticleDOI
CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance.
Carmelo Quarta,Luigi Bellocchio,Luigi Bellocchio,Giacomo Mancini,Roberta Mazza,Cristina Cervino,Luzie J. Braulke,Csaba Fekete,Csaba Fekete,Rocco Latorre,Cristina Nanni,Marco Bucci,Marco Bucci,Laura E. Clemens,Gerhard Heldmaier,Masahiko Watanabe,Thierry Leste-Lassere,Thierry Leste-Lassere,Marlène Maitre,Marlène Maitre,Laura Tedesco,Flaminia Fanelli,Stefan Reuss,Susanne Klaus,Raj Kamal Srivastava,Krisztina Monory,Alessandra Valerio,Alessandra Valerio,Annamaria Grandis,Roberto De Giorgio,Renato Pasquali,Enzo Nisoli,Daniela Cota,Daniela Cota,Beat Lutz,Giovanni Marsicano,Giovanni Marsicano,Uberto Pagotto +37 more
TL;DR: It is shown that conditional mutant mice lacking CB(1) expression in neurons known to control energy balance, but not in nonneuronal peripheral organs, displayed a lean phenotype and resistance to diet-induced obesity.
Journal ArticleDOI
Enteric Glial Cells: Recent Developments and Future Directions
Michel Neunlist,Michel Neunlist,Malvyne Rolli-Derkinderen,Malvyne Rolli-Derkinderen,Rocco Latorre,Laurianne Van Landeghem,Laurianne Van Landeghem,Emmanuel Coron,Emmanuel Coron,Pascal Derkinderen,Roberto De Giorgio +10 more
TL;DR: Emerging concepts as to how EGCs regulate neuromediator expression, exert neuroprotective roles, and even act as neuronal as well as glial progenitors in the enteric nervous system are summarized.
Journal ArticleDOI
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
Nestor N. Jiménez-Vargas,Luke A. Pattison,Peishen Zhao,Tina Marie Lieu,Rocco Latorre,Dane D. Jensen,Joel Castro,Joel Castro,Luigi Aurelio,Giang Thanh Le,Bernard L. Flynn,Carmen Klein Herenbrink,Holly R. Yeatman,Laura E. Edgington-Mitchell,Christopher J.H. Porter,Michelle L. Halls,Meritxell Canals,Nicholas A. Veldhuis,Daniel P. Poole,Daniel P. Poole,Peter McLean,Gareth A. Hicks,Nicole N. Scheff,Elyssa Chen,Aditi Bhattacharya,Brian L. Schmidt,Stuart M. Brierley,Stuart M. Brierley,Stephen Vanner,Nigel W. Bunnett,Nigel W. Bunnett,Nigel W. Bunnett +31 more
TL;DR: The results reveal that PAR2 signaling from endosomes underlies the persistent hyperexcitability of nociceptors that mediates chronic pain of IBS, and reveal the therapeutic potential of endosomally targeted PAR2 antagonists for IBS pain.
Journal ArticleDOI
Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression
Narek Israelyan,Andrew Del Colle,Andrew Del Colle,Zhishan Li,Zhishan Li,Yeji Park,Yeji Park,Albert Xing,Jacob P. R. Jacobsen,Ruth Ann Luna,Dane D. Jensen,Moneek Madra,Moneek Madra,Virginia Saurman,Ray Rahim,Ray Rahim,Rocco Latorre,Kimberly Law,William E. Carson Iv,Nigel W. Bunnett,Marc G. Caron,Kara Gross Margolis +21 more
TL;DR: Evidence is found for reduced release of 5-HT from enteric neurons that results in defects in ENS development and GI motility and in mice studied with an analogous mutation, which results in a 60%-80% decrease in levels in central nervous system and behaviors associated with depression in humans.