Rohan Gala

TL;DR: 28 met- types are defined that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability, and layer-specific axon innervation pattern is identified as a defining feature distinguishing different met-types.

TL;DR: Here, neuron-type-specific patterns of NP gene expression are used to offer specific, testable predictions regarding 37 peptidergic neuromodulatory networks that may play prominent roles in cortical homeostasis and plasticity.

TL;DR: The results show that when the density of labeled neurites is sufficiently low, automated traces are not significantly different from manual reconstructions obtained by trained users.

TL;DR: This work characterized the transcriptomes and intrinsic physiological properties of over 3,700 GABAergic mouse visual cortical neurons and reconstructed the local morphologies of 350 of those neurons, finding that most transcriptomic types (t-types) occupy specific laminar positions within mouse visual cortex, and many of those t-types exhibit consistent electrophysiological and morphological features.

TL;DR: This work presents an optimization framework to learn coordinated representations of multimodal data and applies it to a large multimodals dataset profiling mouse cortical interneurons, revealing strong alignment between transcriptomic and electrophysiological characterizations and enabling accurate cross-modal data prediction.