Lydia Potekhina

TL;DR: A single-cell characterization pipeline is established using standardized patch-clamp recordings in brain slices and biocytin-based neuronal reconstructions to establish a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features.

TL;DR: A high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development is described that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease.

TL;DR: 28 met- types are defined that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability, and layer-specific axon innervation pattern is identified as a defining feature distinguishing different met-types.

TL;DR: In this article, a robust platform combining patch clamp recording, biocytin staining and single-cell RNA-sequencing (Patch-seq) was developed to examine neurosurgically resected human tissues.

TL;DR: A comprehensive neuropathological, molecular, and transcriptomic characterization of hippocampus and two regions cortex in 107 aged donors from the Adult Changes in Thought study is generated, highlighting the importance of properly controlling for RNA quality when studying dementia.