Lindsay Ng

TL;DR: A single-cell characterization pipeline is established using standardized patch-clamp recordings in brain slices and biocytin-based neuronal reconstructions to establish a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features.

TL;DR: 28 met- types are defined that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability, and layer-specific axon innervation pattern is identified as a defining feature distinguishing different met-types.

TL;DR: An open, large-scale physiological survey of neural activity in the awake mouse visual cortex: the Allen Brain Observatory Visual Coding dataset is reported, revealing functional differences across these dimensions and showing that visual cortical responses are sparse but correlated.

TL;DR: In this article, a robust platform combining patch clamp recording, biocytin staining and single-cell RNA-sequencing (Patch-seq) was developed to examine neurosurgically resected human tissues.

TL;DR: A large, open dataset that surveys spiking from units in six cortical and two thalamic regions responding to a battery of visual stimuli finds that inter-area functional connectivity mirrors the anatomical hierarchy from the Allen Mouse Brain Connectivity Atlas and provides a foundation for understanding coding and dynamics in the mouse cortico-thalamic visual system.