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Tim Jarsky
Researcher at Allen Institute for Brain Science
Publications - 31
Citations - 2609
Tim Jarsky is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Neocortex & Excitatory postsynaptic potential. The author has an hindex of 9, co-authored 23 publications receiving 1659 citations. Previous affiliations of Tim Jarsky include Allen Institute for Artificial Intelligence.
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Journal ArticleDOI
Adult mouse cortical cell taxonomy revealed by single cell transcriptomics
Bosiljka Tasic,Vilas Menon,Thuc Nghi Nguyen,Tae Kyung Kim,Tim Jarsky,Zizhen Yao,Boaz P. Levi,Lucas T. Gray,Staci A. Sorensen,Tim A. Dolbeare,Darren Bertagnolli,Jeff Goldy,Nadiya V. Shapovalova,Sheana Parry,Changkyu Lee,Kimberly A. Smith,Amy Bernard,Linda Madisen,Susan M. Sunkin,Michael Hawrylycz,Christof Koch,Hongkui Zeng +21 more
TL;DR: This work constructed a cellular taxonomy of one cortical region, primary visual cortex, in adult mice on the basis of single-cell RNA sequencing and identified 49 transcriptomic cell types, including 23 GABAergic, 19 glutamatergic and 7 non-neuronal types.
Journal ArticleDOI
Classification of electrophysiological and morphological neuron types in the mouse visual cortex.
Nathan W. Gouwens,Staci A. Sorensen,Jim Berg,Changkyu Lee,Tim Jarsky,Jonathan T. Ting,Susan M. Sunkin,David Feng,Costas A. Anastassiou,Eliza Barkan,Kris Bickley,Nicole Blesie,Thomas Braun,Krissy Brouner,Agata Budzillo,Shiella Caldejon,Tamara Casper,Dan Castelli,Peter Chong,Kirsten Crichton,Christine Cuhaciyan,Tanya L. Daigle,Rachel A. Dalley,Nick Dee,Tsega Desta,Songlin Ding,Samuel Dingman,Alyse Doperalski,Nadezhda Dotson,Tom Egdorf,Michael S. Fisher,Rebecca de Frates,Emma Garren,Marissa Garwood,Amanda Gary,Nathalie Gaudreault,Keith B. Godfrey,Melissa Gorham,Hong Gu,Caroline Habel,Kristen Hadley,James Harrington,Julie A. Harris,Alex M. Henry,DiJon Hill,Samuel R Josephsen,Sara Kebede,Lisa Kim,Matthew Kroll,Brian Lee,Tracy Lemon,Katherine E. Link,Xiaoxiao Liu,Brian Long,Rusty Mann,Medea McGraw,Stefan Mihalas,Alice Mukora,Gabe J. Murphy,Lindsay Ng,Kiet Ngo,Thuc Nghi Nguyen,Philip R. Nicovich,Aaron Oldre,Daniel Park,Sheana Parry,Jed Perkins,Lydia Potekhina,David Reid,Miranda Robertson,David Sandman,Martin Schroedter,Cliff Slaughterbeck,Gilberto J. Soler-Llavina,Josef Sulc,Aaron Szafer,Bosiljka Tasic,Naz Taskin,Corinne Teeter,Nivretta Thatra,Herman Tung,Wayne Wakeman,Grace Williams,Rob Young,Zhi Zhou,Colin Farrell,Hanchuan Peng,Michael Hawrylycz,Ed Lein,Lydia Ng,Anton Arkhipov,Amy Bernard,John W. Phillips,Hongkui Zeng,Christof Koch +94 more
TL;DR: A single-cell characterization pipeline is established using standardized patch-clamp recordings in brain slices and biocytin-based neuronal reconstructions to establish a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features.
Journal ArticleDOI
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells.
Nathan W. Gouwens,Staci A. Sorensen,Fahimeh Baftizadeh,Agata Budzillo,Brian Lee,Tim Jarsky,Lauren Alfiler,Katherine Baker,Eliza Barkan,Kyla Berry,Darren Bertagnolli,Kris Bickley,Jasmine Bomben,Thomas Braun,Krissy Brouner,Tamara Casper,Kirsten Crichton,Tanya L. Daigle,Rachel A. Dalley,Rebecca de Frates,Nick Dee,Tsega Desta,Samuel Dingman Lee,Nadezhda Dotson,Tom Egdorf,Lauren Ellingwood,Rachel Enstrom,Luke Esposito,Colin Farrell,David Feng,Olivia Fong,Rohan Gala,Clare Gamlin,Amanda Gary,Alexandra Glandon,Jeff Goldy,Melissa Gorham,Lucas T. Graybuck,Hong Gu,Kristen Hadley,Michael Hawrylycz,Alex M. Henry,DiJon Hill,Madie Hupp,Sara Kebede,Tae Kyung Kim,Lisa Kim,Matthew Kroll,Changkyu Lee,Katherine E. Link,Matthew Mallory,Rusty Mann,Michelle Maxwell,Medea McGraw,Delissa McMillen,Alice Mukora,Lindsay Ng,Lydia Ng,Kiet Ngo,Philip R. Nicovich,Aaron Oldre,Daniel Park,Hanchuan Peng,Osnat Penn,Thanh Pham,Alice Pom,Zoran Popović,Lydia Potekhina,Ramkumar Rajanbabu,Shea Ransford,David Reid,Christine Rimorin,Miranda Robertson,Kara Ronellenfitch,Augustin Ruiz,David Sandman,Kimberly A. Smith,Josef Sulc,Susan M. Sunkin,Aaron Szafer,Michael Tieu,Amy Torkelson,Jessica Trinh,Herman Tung,Wayne Wakeman,Katelyn Ward,Grace Williams,Zhi Zhou,Jonathan T. Ting,Anton Arkhipov,Uygar Sümbül,Ed S. Lein,Christof Koch,Zizhen Yao,Bosiljka Tasic,Jim Berg,Gabe J. Murphy,Hongkui Zeng +97 more
TL;DR: 28 met- types are defined that have congruent morphological, electrophysiological, and transcriptomic properties and robust mutual predictability, and layer-specific axon innervation pattern is identified as a defining feature distinguishing different met-types.
Journal ArticleDOI
Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex.
Stephanie C. Seeman,Luke Campagnola,Pasha A. Davoudian,Alex Hoggarth,Travis A. Hage,Alice Bosma-Moody,Christopher A. Baker,Jung Hoon Lee,Stefan Mihalas,Corinne Teeter,Andrew L. Ko,Jeffrey G. Ojemann,Jeffrey G. Ojemann,Ryder P. Gwinn,Daniel L. Silbergeld,Charles Cobbs,John W. Phillips,Ed Lein,Gabe J. Murphy,Christof Koch,Hongkui Zeng,Tim Jarsky +21 more
TL;DR: It is found that connections are sparse but present among all excitatory cell classes and layers the authors sampled, and that most mouse synapses exhibited short-term depression with similar dynamics, contributing to a body of evidence describing recurrent exciteatory connectivity as a conserved feature of cortical microcircuits.
Journal ArticleDOI
Human neocortical expansion involves glutamatergic neuron diversification
Jim Berg,Staci A. Sorensen,Jonathan T. Ting,Jonathan T. Ting,Jeremy A. Miller,Thomas Chartrand,Anatoly Buchin,Trygve E. Bakken,Agata Budzillo,Nick Dee,Songlin Ding,Nathan W. Gouwens,Rebecca D. Hodge,Brian E. Kalmbach,Brian E. Kalmbach,Changkyu Lee,Brian Lee,Lauren Alfiler,Katherine Baker,Eliza Barkan,Allison Beller,Kyla Berry,Darren Bertagnolli,Kris Bickley,Jasmine Bomben,Thomas Braun,Krissy Brouner,Tamara Casper,Peter Chong,Kirsten Crichton,Rachel A. Dalley,Rebecca de Frates,Tsega Desta,Samuel Dingman Lee,Florence D’Orazi,Nadezhda Dotson,Tom Egdorf,Rachel Enstrom,Colin Farrell,David Feng,Olivia Fong,Szabina Furdan,Anna A. Galakhova,Clare Gamlin,Amanda Gary,Alexandra Glandon,Jeff Goldy,Melissa Gorham,Natalia A. Goriounova,Sergey L. Gratiy,Lucas T. Graybuck,Hong Gu,Kristen Hadley,Nathan Hansen,Tim S. Heistek,Alex M. Henry,Djai B. Heyer,Di Jon Hill,Chris Hill,Madie Hupp,Tim Jarsky,Sara Kebede,Lisa Keene,Lisa Kim,Mean Hwan Kim,Matthew Kroll,Caitlin S. Latimer,Boaz P. Levi,Katherine E. Link,Matthew Mallory,Rusty Mann,Desiree A. Marshall,Michelle Maxwell,Medea McGraw,Delissa McMillen,Erica J. Melief,Eline J. Mertens,Leona Mezei,Norbert Mihut,Stephanie Mok,Gábor Molnár,Alice Mukora,Lindsay Ng,Kiet Ngo,Philip R. Nicovich,Julie Nyhus,Gáspár Oláh,Aaron Oldre,Victoria Omstead,Attila Ozsvár,Daniel Park,Hanchuan Peng,Trangthanh Pham,Christina A. Pom,Lydia Potekhina,Ramkumar Rajanbabu,Shea Ransford,David Reid,Christine Rimorin,Augustin Ruiz,David Sandman,Josef Sulc,Susan M. Sunkin,Aaron Szafer,Viktor Szemenyei,Elliot R. Thomsen,Michael Tieu,Amy Torkelson,Jessica Trinh,Herman Tung,Wayne Wakeman,Femke Waleboer,Katelyn Ward,René Wilbers,Grace Williams,Zizhen Yao,Jae Geun Yoon,Costas A. Anastassiou,Anton Arkhipov,Pál Barzó,Amy Bernard,Charles Cobbs,Philip C. De Witt Hamer,Richard G. Ellenbogen,Luke Esposito,Manuel Ferreira,Ryder P. Gwinn,Michael Hawrylycz,Patrick R. Hof,Sander Idema,Allan R. Jones,C. Dirk Keene,Andrew L. Ko,Gabe J. Murphy,Gabe J. Murphy,Lydia Ng,Jeffrey G. Ojemann,Anoop P. Patel,John W. Phillips,Daniel L. Silbergeld,Kimberly A. Smith,Bosiljka Tasic,Rafael Yuste,Idan Segev,Christiaan P. J. de Kock,Huibert D. Mansvelder,Gábor Tamás,Hongkui Zeng,Christof Koch,Ed S. Lein,Ed S. Lein +150 more
TL;DR: In this article, a robust platform combining patch clamp recording, biocytin staining and single-cell RNA-sequencing (Patch-seq) was developed to examine neurosurgically resected human tissues.